PlasmidFactory is working on the following research topics – in close co-operation with industrial and academic partners.

Transient AAV production
Development of non-viral vector systems free of resistence gene sequences (e.g. minicircle)
Research on long-term storage of plasmid DNA and parameters influencing the stability (e.g. plasmid size, DNA concentration, storage buffer)
Influence of freeze and thaw conditions on plasmid topology
DNA vaccine development for cat fibrosarcoma
Production of dimer or multimer plasmids (e.g. reporter gene vectors)
Application of capillary gel electrophoresis (CGE)
Optimization of vectors for co-transfection, e.g. for production of viruses (AAV, LV) or antibodies
Optimization of lentiviral vector systems
Vector development for hepatitis vaccines
Clinical and pre-clinical research for non-viral vectors

Furthermore, PlasmidFactory co-operates with national and international partners on individual projects.

We gratefully acknowledge the support from German Ministry of Research and Education (BMBF), German Ministry of Economics and Technology (BMWi), European Commission (CLINIGENE, Network of Excellence, founded under the FP6).

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