SCIREQ - an emka TECHNOLOGIES Company articles
While the dangers of primary smoking are well-known, nearly half of the U.S. population remains at risk from the silent threat of secondhand smoke (SHS). Chronic exposure to SHS triggers a cascade of inflammation and vascular damage that can lead to irreversible conditions like COPD and emphysema.
A recent study from Sturgis et al. (2025) has demonstrated a p
In the world of preclinical lung cancer research, seeing a tumor is only half the battle. While traditional imaging like microCT can show us where a mass is located, it often fails to tell the full story: How is that tumor actually affecting the animal’s ability to breathe?
A recent pilot study by
Abstract
Cannabis is used by an estimated 192 million people around the world. Most people use cannabis through the inhalation of cannabis smoke, which contains combustion by-products that can negatively affect lung health. Knowledge of these risks has led to a growing interest in cannabis vaporizers, which heat the dry cannabis flower without burning. Vaporizing cannabis still releases cannabinoids for inhalation but heats the plant material at a lower temperature. T
Emily T. Wilson;Ilan B. Urovitch;Percival Graham;Rui Liu;Cory S. Harris;David H. Eidelman;Carolyn J. Baglole
Idiopathic pulmonary fibrosis (IPF) is a devasting lung disease characterized by progressive scarring of lung tissue. As fibrosis develops, patients experience worsening shortness of breath, reduced lung capacity and ultimately respiratory failure. Current therapies for IPF rely on oral administration of pirfenidone and nintedanib, two FDA-approved drugs that slow disease progression. While effective, oral dosing requires high systematic concentrations, which often lead to gastrointestinal si
In preclinical respiratory studies, traditional methods like plethysmography often require animal restraint and extensive acclimation, limiting their ability to capture dynamic respiratory changes.
To overcome these challenges, IPS Therapeutique Inc. validated a novel telemetry-based technique for continuous monitoring of intrapleural pressure and respiratory patterns in conscious, freel
Obesity is a significant contributor to respiratory disorders such as Obesity Hypoventilation Syndrome (OHS) and sleep apnea, both of which are characterized by reduced respiratory chemosensitivity. These conditions not only impair breathing but also exacerbate the health risks associated with obesity. Recent research from
Precision-Cut Lung Slices (PCLS) have emerged as a innovative ex vivo model that allows researchers to explore deep into lung physiology, disease mechanisms, and pharmacological responses. By offering a unique combination of biological complexity and controlled experimental conditions, PCLS serve as a critical bridge between the limitations of traditional in vitro
Despite international treaties, the use of chemical weapons remains a concern nowadays. Organophosphorus-nerve agents (OPs) act by inhibiting cholinesterases (ChE), preventing the degradation of some neurotransmitters. Their excessive accumulation can impair neuronal transmission, leading to cholinergic syndrome, which can cause symptoms such as respiratory failure and, in severe cases, death.
Oximes are molecules that can reverse the effect of OPs. While they can be used as treatment
Pulmonary fibrosis, particularly idiopathic pulmonary fibrosis (IPF), represents a significant challenge in healthcare due to its detrimental impact on lung function and limited treatment options. While WNT/β-catenin signaling plays a crucial role in lung development and maintenance of adult lung stem cells, its dysregulation has been associated with pulmonary fibrosis. However, recent research has revealed a potential therapeutic avenue through the modulation of this signaling pathway.<
Asthma, affecting over 300 million individuals globally, remains a significant health concern with a high mortality rate. Despite advancements in treatment, many patients still struggle with symptom control and recurrent attacks. While inflammation has been the focal point of asthma research, a recent study sheds light on a mechanical aspect that could refine our understanding and treatment of the condition.
Asthma exacerbation