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Circulating platelet microRNAs (thrombomiRs®) are novel biomarkers for intrinsic and on-treatment platelet reactivity. thrombomiRs® are secreted from platelets during their activation and can be detected in plasma and serum. Commonly used platelet function tests e.g. LTA, VerifyNow® or PFA-100®, require fresh blood and agonists. Therefore, they clearly lack standardization and ...
Human CXCL4, additionally known as Platelet-factor 4, is a 70 amino acid protein that is released by activated platelets to promote coagulation. CXCL4 binds to the G protein-coupled receptor CXCR3-B, found in kidney, heart and liver tissue, but a canonical signaling receptor is still unknown. CXCL4 readily binds to heparin-like molecules and glycoproteins and is a regulator of endothelial and ...