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Cypre’s 3D Tumor Models combine the tumor, stromal and immune compartments in a high throughput format to screen targeted drugs and immunotherapy. In 2021, we partnered with Charles River to offer our 3D Tumor Models for drug discovery and preclinical screening services. ...
RMC-9805 is a novel, mutant-selective, covalent and oral KRASG12D (ON) inhibitor. A stable and high affinity triple complex is formed between RMC-9805, KRASG12D, and cyclophilin A, which inhibits signal transduction downstream of KRASG12D (ON) by disrupting its interaction with downstream effectors. RMC-9805 can induce cell apoptosis and promote tumor regression in preclinical KRASG12D tumor ...
OncoPeptTUME — A novel in-silico approach to model the tumor microenvironment and predict treatment efficacy and long-term survival benefits for immunotherapy applications. Cancer immunotherapy is now established as a major therapeutic modality. Cancer immunotherapy drugs elicit their anti-tumor immune response in a subset of the treated patients by activating CD8 T-cells and provide ...
Alpha-Feto Protein (AFP) is a 70,000 kDa glycoprotein molecule which is closely related to human albumin both genetically and structurally. AFP is produced initially by the fetal yolk sac in small quantities and then in large quantities by the fetal liver as the yolk sac degenerates. The peak concentration in the fetal serum is approximately 3,000,000 ng / ml, and it is reached at this level ...
Carcinoembroyonic antigen (CEA) is a 150300 kD glycoprotein molecule which has been found by Gold and Freedman at 1965 and it is also known as major component of CEA glycoprotein family. This family consists of 36 different glycoproteins with the common feature of close similarity of their structural domain to IgG heavy chain structure. Carbohydrate constitutes 45-55% of the ...
The IsoFlux System enriches intact rare cells from biological samples and prepares them for further analysis. It gives you immediate access to high quality, viable cells in a high-density format, ready for use in the application of your choice. For use with IsoFlux Enrichment Kits containing micro-fluidic cartridges for rare cell ...