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Background information The only effective way to combat a disease like cancer is to understand it. And as we work to understand cancer, analyzing DNA methylation has come to play an increasingly important role, providing more meaningful information on tumorigenesis, tumor progression and metastasis. ...
Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 3,4,5-trisphosphate (PIP3), formed from PI(4,5)P2 though phosphorylation by PI 3-kinase, activates numerous signaling pathways resulting in cell proliferation, growth, survival, glucose transport and protein synthesis. High PIP3 levels from ...
Next-generation sequencing (NGS) has the potential to revolutionize the diagnosis and treatment of cancers and rare diseases but creates extremely large, complex, and noisy datasets for analysis. Without the right analytical technology, pinpointing causative variants and obtaining actionable insights from NGS data requires specialist skills, multiple resources, and considerable time. The ...
Therapeutic antibodies are monoclonal antibodies developed to attack specific cells or proteins for the treatment of a wide variety of diseases, including immune disorders, cancers, and ...
CD Genomics's cancer panels are predesigned panels for targeted sequencing of genes and mutations associated with multiple cancer diseases. CD Genomics utilizes targeted NGS sequencing technology to provide more efficient and accurate targeting of specific genes or mutations, and even to detect low-frequency variations in cancer-associated genes. ...
The Disease Panel provides one-stop solutions (including both services and reagents) for the study of a wide range of diseases, including cancer, inherited disease, and infection by using NGS panels or non-NGS panels, which facilitate numerous applications such as disease research, biomarker discovery, and targeted drug development. https://www.cd-genomics.com/diseasepanel/custom-ngs-panel.html ...
Cancer immunology, or “immuno-oncology,” is a growing field of research that aims to discover innovative cancer immunotherapies to treat and impede the progression of the disease. Understanding how cancer evades the immune system is the basis of immuno-oncology. With Indivumed’s scientific support you can, for example, identify the different types of immune cells and their ...
EAPII (also called TTRAP, TDP2) originally was identified as an interacting partner of oncogene ETS1, a founding member of ets transcription factor, and the cytoplasmic domain of CD40, a member of the tumor necrosis factor (TNF) receptor family. EAPII significantly represses ETS1 transcriptional activity and the synergistic transactivation by ETS1 and AP-1 or by ETS1 and NFκB. EAPII/TTRAP ...
Cell-free DNA (cfDNA), found circulating in blood plasma, contains a wealth of clinically relevant biological information which can be recovered by minimally-invasive procedures. Next Generation Sequencing (NGS) data obtained from cfDNA, can be used to monitor prenatal health, organ transplant reception or rejection, cancer and other ...
IgE constitutes a fraction of the total antibody in serum 50-300 ng/ml (compared to 10 mg/ml for IgG) and together with its Fc receptor is important in primary immune responses. The immunogenetic mechanisms underlying IgE responsiveness seen in the atopic diseases can be divided into antigen-specific and nonantigen-specific responses. IgE antibodies to common antigens are reported in the serum of ...
SoBran’s facilities can house a broad range of projects supporting:Partnering for Your suCCess, Motivated bY disCoverYSoBran, Inc.2677 Prosperity AvenueSuite 200Fairfax, VA 22031Ph: 703.352.9511Fax: 703.352.9513ask@sobranbioscience.com www.sobranbioscience.comOur leading-edge facility provides:n Exclusive use of ventilated micro-isolator caging supporting ABSL I and II environments n Automated ...