hepatic-metabolism Downloads
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Fentanyl is a synthetic opioid related to the phenylpiperidines. Fentanyl is approximately 100 times more potent than morphine. This agent is highly lipid soluble and rapidly cross the blood-brain barrier. This is reflected in the half-life for equilibration between the plasma and cerebrospinal fluid of approximately 5 minutes for fentanyl. The levels in plasma and cerebrospinal fluid decline ...