Airway Epithelial Articles & Analysis
4 news found
Relentless efforts in seeking therapies to minimize symptoms or to cure CF are often hindered by the barriers imposed by the specialized cells, secreted host defense factors and mucociliary transport system lining the airway of CF patients. Therefore, developing an efficient pulmonary delivery agent is instrumental in the advancement of treatments for CF. The Feldan Shuttle ...
Paul McCray and Feldan Therapeutics have demonstrated that the Feldan Shuttle technology enables the delivery of functional proteins and CRISPR nucleases to human airway epithelial cells, which opens the door to the development of revolutionary therapies in the pulmonary field. ...
Ian McGowan MD PhD, Chief Medical Officer at Orion Biotechnology added, “The pathogenesis of SARS-CoV-2 associated ARDS includes the development of a cytokine/chemokine “storm” from infected airway epithelial cells, dendritic cells, and macrophages. Given the upregulation of CCL5 in this situation, treatment with OB-002 has the potential to ...
Paul McCray, from the University of Iowa Carver College of Medicine, demonstrate that Feldan’s engineered amphiphilic peptides (Feldan Shuttles) allow safe and efficient intracellular delivery of proteins to airway epithelia. The authors declare: "The delivery of biologic cargoes to airway epithelial cells is challenging due to the ...