Cancer Associated Gene Articles & Analysis
4 news found
P53 is a potent tumor suppressor encoded by the TP53 gene on human chromosome 17. As a transcription factor, P53 coordinates the expression of target genes to promote cell cycle arrest, apoptosis, and DNA repair. ...
At present, the research on the mechanism of abnormal cell proliferation, differentiation, and carcinogenesis is mainly divided into three categories: activation of dominant transformation proto-oncogene through translocation and mutation, inactivation of tumor suppressor gene through mutation, and disorder of DNA repair gene. CD Genomics’ ...
Molecular Health GmbH announced today that it has entered into an agreement with Kyoto-based FALCO biosystems Ltd. under which FALCO biosystems will use the products MH Guide/BRCA and MH Guide/Mendel to evaluate inherited genetic variants of BRCA1/2 and other heritable cancer-associated genes. Inherited genetic variants can predispose an ...
The study, published online Aug. 28, 2011, in Nature Genetics, describes two U.S. families with a high incidence of mesothelioma, as well as other cancers, associated with mutations of the BAP1 gene. The research was funded by the National Cancer Institute (NCI), part of the National Institutes of Health, and led by scientists at ...