Cancer Stem Cell Marker Articles & Analysis
5 news found
Carina’s CAR-T cells are targeted at LGR5, a cancer stem cell marker that is highly expressed on colorectal cancer and other cancers. ...
Highlights Five conference abstracts will be presented as poster presentations at AACR in the immuno-oncology and preclinical immunotherapy sessions Four presentations describe preclinical data from Carina’s LGR5-targeted CAR-T cell program, one poster will describe preclinical data from Carina’s ADAM-10 CAR-T program With its LGR5 CAR-T, Carina is progressing ...
About Carina’s LGR5 CAR-T cell LGR5 is a cancer stem cell marker that is highly expressed on advanced colorectal cancer and some other cancers. ...
Lentiviruses are widely used as a tool to deliver genes of interest to cells. In this case, the lentivirus transduces (or inserts) a group of genes to a patient’s T cells (immune cells), which turn the T cells into cancer-killing CAR-T cells targeting LGR5, a cancer ...
“At Carina Biotech, we are focused on our goal of creating a future that defeats cancer. The LGR5 CAR-T cell for advanced colorectal cancer is a great place to start, given this cancer’s very poor prognosis and rising incidence, particularly in younger people. ...