Cornea Repair Articles & Analysis
4 news found
(“BRIM,” TPEx 6885) is pleased to announce that the US Food and Drug Administration (FDA) has granted Orphan Drug Designation (ODD) for BRM424 in the treatment of neurotrophic keratitis (NK), a rare degenerative eye disease which causes very severe cornea damage and can lead to loss of sight. Dr. Haishan Jang, Chairwoman and CEO of BRIM Biotechnology, commented, ...
It stimulates stem cell differentiation, repairs the cornea, inhibits inflammation, and promotes recovery in DED. Phase 2 clinical trial results have shown that BRM421 not only significantly improved DED symptoms including dryness, burning/stinging, and photophobia within one week of treatment, but also showed efficacy in repairing the ...
” BRM421 is a novel, first-in-class regenerative peptide therapy which, if successful, could offer patients full relief of symptoms plus repair the damage to the cornea. BRM421 is derived from BRIM’s proprietary, stem cell regenerative PEDF-derived Short Peptides (PDSPs), which can also be applied across multiple therapy areas and indications. In the ...
The functional domain of PEDF chosen to generate PDSPs can be used to treat dry eye disease by speeding up the cornea repair process through stimulation of corneal stem cell proliferation and differentiation, anti-inflammation and meibomian gland recovery.?? ...