Cytokine Profile Articles & Analysis
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” Addition of AKTi during manufacturing results in improved phenotype and proliferative potential of SPEAR T-cells – attributes that may contribute to more sustained antitumor immune responses In vitro analyses of manufactured product samples ADP-A2M4CD8 SPEAR T-cells were manufactured with and without AKTi Samples manufactured with AKTi expanded more effectively during ...
SPEARHEAD-1 trial will meet its primary endpoint and data will be used to support BLA filing for afami-cel next year The overall response rate (ORR) per Independent Review was 34% (36% in patients with synovial sarcoma and 25% for patients with MRCLS) and the disease control rate was 85% As of the data cut-off, afami-cel has shown a favorable benefit:risk profile ...