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Drug Concentration Articles & Analysis

13 news found

CD Formulation Enables Efficacy Evaluation of Oral Thin Films: Ensuring Therapeutic Efficacy and Safety

CD Formulation Enables Efficacy Evaluation of Oral Thin Films: Ensuring Therapeutic Efficacy and Safety

Traditional methods of evaluating the efficacy of oral medications have often been limited by the inability to accurately measure the drug's concentration in the body. This has led to challenges in determining the optimal dosage and timing of administration, which can impact both the effectiveness and safety of the treatment. ...

ByCD Formulation


CD Formulation Exhibits Proficiency in Contact Angle Determination of Pharmaceutical Excipients

CD Formulation Exhibits Proficiency in Contact Angle Determination of Pharmaceutical Excipients

We seize every opportunity to apply the latest science and technology to the pharmaceutical industry through our diversified drug analysis service portfolios in the hope of advancing the global healthcare business," said a spokesperson for CD Formulation. ...

ByCD Formulation


Differences Between Spinal Blocks & Epidurals

Differences Between Spinal Blocks & Epidurals

But the epidural name only refers to using the epidural space of the spine to administer pain relief drugs. Where that relief is targeted is dependent on where a particular procedure is being performed; in a lung operation, for example, the chest cavity can be anesthetized. ...

ByMilestone Scientific, Inc.


Cingulate Completes Fed/Fast Study Assessing Food Effect with CTx-1301, Lead Candidate for Treatment of ADHD

Cingulate Completes Fed/Fast Study Assessing Food Effect with CTx-1301, Lead Candidate for Treatment of ADHD

Subjects were randomized into one of two sequences (a fasted state, and a fed state [after a high-fat test meal]) and dosed with a 25mg dose of CTx-1301 The primary PK endpoints were maximum concentration (expressed as Cmax) during the first 28 hours after dosing, and the total amount of the active pharmaceutical ingredient (API), dexmethylphenidate, in the blood (expressed as ...

ByCingulate


Rani Therapeutics Unveils High-Capacity RaniPill Device for Oral Delivery of Biologics

Rani Therapeutics Unveils High-Capacity RaniPill Device for Oral Delivery of Biologics

“The RaniPill HC gives us the potential to deliver a much broader range of biologic drugs with its higher capacity of up to 20 mg of drug per capsule,” said Mir Imran, Rani’s Founder and Executive Chairman. ...

ByRani Therapeutics


Rani Therapeutics develops oral biologics delivery device

Rani Therapeutics develops oral biologics delivery device

The new device is capable of delivering a drug payload of up to or more than 500% higher compared to the company’s current oral biologics capsule. ...

ByRani Therapeutics


Saladax Biomedical and HLS Therapeutics Strengthen Partnership With an Exclusive Distribution Agreement for Canada

Saladax Biomedical and HLS Therapeutics Strengthen Partnership With an Exclusive Distribution Agreement for Canada

Unfortunately, these medications can have adverse effects if the drug level is too high. Conversely, if the drug level is too low, the patient’s condition may not be treated effectively. Current drug level methods are not rapid enough, which diminishes their clinical utility. ...

BySaladax Biomedical, Inc.


Senti Bio and BlueRock Therapeutics Enter Collaboration to Develop Gene Circuit-Engineered Cell Therapies for Regenerative Medicine

Senti Bio and BlueRock Therapeutics Enter Collaboration to Develop Gene Circuit-Engineered Cell Therapies for Regenerative Medicine

For example, Regulator Dials can be engineered to regulate therapeutic payload expression in response to varying concentrations of FDA-approved drugs. Regulator Dials are expected to enable the exogenous regulation of next-generation cell and gene therapies even after they have been delivered in vivo. ...

ByBlueRock Therapeutics


Avelas Receives FDA Breakthrough Therapy Designation for Pegloprastide (AVB-620) for Use During Breast Cancer Surgery

Avelas Receives FDA Breakthrough Therapy Designation for Pegloprastide (AVB-620) for Use During Breast Cancer Surgery

A Breakthrough Therapy designation provides more intensive FDA guidance on an efficient drug development program, an organizational commitment involving senior managers, and eligibility for rolling review and priority review. ...

ByAvelas Biosciences


Avelas Announces Top-Line Data Showing Pegloprastide (AVB-620) Can Significantly Improve Cancer Detection in Real-Time During Breast Cancer Surgery

Avelas Announces Top-Line Data Showing Pegloprastide (AVB-620) Can Significantly Improve Cancer Detection in Real-Time During Breast Cancer Surgery

Pegloprastide’s ratiometric readout attenuates common artifacts of fluorescent imaging, including differences in drug concentration and distance of the camera from the tissue area of interest. ...

ByAvelas Biosciences


Onapristone Extended Release: Safety Evaluation from Phase I–II Studies with an Emphasis on Hepatotoxicity

Onapristone Extended Release: Safety Evaluation from Phase I–II Studies with an Emphasis on Hepatotoxicity

Evaluation of antiprogestin pharmacology and pharmacokinetic data suggested that liver enzyme elevations might be related to off-target or metabolic effects associated with clinical drug exposure. Objective We explored whether the use of a pharmaceutic strategy targeting efficacious systemic dose concentrations, but with diminished peak serum ...

ByContext Therapeutics Inc.


Aeration may remove antidepressant drugs from water leaked from landfill

Aeration may remove antidepressant drugs from water leaked from landfill

Aeration is an effective means of eliminating antidepressants from landfill leachate, a new study finds. The concentrations of five different drugs were reduced by this treatment process, which could be an effective means of tackling the growing problem of pharmaceutical infiltration into aquatic environments. ...

ByEuropean Commission, Environment DG


Pesticides and pharmaceuticals influence riverbed communities of microbes

Pesticides and pharmaceuticals influence riverbed communities of microbes

Painkillers and anti-inflammatory drugs were found to have a significant effect on the structure and functioning of the biofilms. ...

ByEuropean Commission, Environment DG

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