Companies
MedChemExpress LLC (MCE)
Products
MedChemExpress - Model Lupeol acetate - ...

MedChemExpress - Model Lupeol acetate -1617-68-1

Lupeol acetate is a derivative of Lupeol. Lupeol acetate is an anti-inflammatory, antibacterial, anti-trypanosomic and anticancer agent with oral activity. Lupeol acetate significantly improves the symptoms of rheumatoid arthritis by down-regulating the expression of inflammatory cytokines and osteoclast production. Lupeol acetate inhibits spermatogenesis in male rats and eventually led to infertility[1][2][3][4].

Lupeol acetate

MCE China：Lupeol acetate

Brand：MedChemExpress (MCE)

Cat. No.HY-126114

CAS：1617-68-1

Purity：98.0%

Storage：Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Lupeol acetate is a derivative of Lupeol. Lupeol acetate is an anti-inflammatory, antibacterial, anti-trypanosomic and anticancer agent with oral activity. Lupeol acetate significantly improves the symptoms of rheumatoid arthritis by down-regulating the expression of inflammatory cytokines and osteoclast production. Lupeol acetate inhibits spermatogenesis in male rats and eventually led to infertility.

In Vitro：Lupeol acetate (3.125-100mg/mL; 7 days) inhibits the growth of M. phaseolina with a bacteriostatic rate of 79-81%[1]. Lupeol acetate (3-94 µg/mL; 24-48 h) induces death of trypomastigote with an EC50 of 15.82 µg/mL and an inhibition of amastigote stage with an IC50 of 32.55 µg/mL[2]. Lupeol acetate (0-80 μM; 25 h) inhibits the activation and expression of TNF-α and IL-1β in LPS (HY-D1056) -treated RAW 264.7 and BMDMs cells[3]. Lupeol acetate (0-80 μM; 25 h) decreases the migration ability of macrophages by down-regulating the expression of COX-2 and MCP-1 and blocks osteoclast differentiation mediated by RANKL[3].

In Vivo：Lupeol acetate (50 mg/kg; Intraperitoneal injection; 21 days) shows improvement in the mouse model of rheumatoid arthritis[3]. Lupeol acetate (10 mg/day; Oral administration; 60 days) plays an anti-fertility role in male rats[4].

IC50 & Target：COX-2

References：

[1]. Javed S, et al. Lupeol acetate as a potent antifungal compound against opportunistic human and phytopathogenic mold Macrophomina phaseolina. Sci Rep. 2021 Apr 19;11(1):8417. [Content Brief]

[2]. Pardo-Rodriguez D, et al. Lupeol Acetate and α-Amyrin Terpenes Activity against Trypanosoma cruzi: Insights into Toxicity and Potential Mechanisms of Action. Trop Med Infect Dis. 2023 May 3;8(5):263. [Content Brief]

[3]. Wang WH, et al. Lupeol acetate ameliorates collagen-induced arthritis and osteoclastogenesis of mice through improvement of microenvironment. Biomed Pharmacother. 2016;79:231-240. [Content Brief]

[4]. Gupta RS, et al. Induction of antifertility with lupeol acetate in male albino rats. Pharmacology. 2005 Oct;75(2):57-62. [Content Brief]

Brand introduction:
•   MCE (MedChemExpress) has a global exclusive compound library of more than 200 kinds, and we are committed to providing the most comprehensive range of high-quality small molecule active compounds for scientific research customers around the world；
•   More than 50,000 highly selective inhibitors and agonists are involved in various popular signaling pathways and disease areas；
•   The products cover a variety of recombinant proteins, peptides, commonly used kits, more PROTAC, ADC and other characteristic products, widely used in new drug research and development, life science and other scientific research projects；
•   Provide virtual screening, ion channel screening, metabolomics analysis detection analysis, drug screening and other professional technical services；
•   It has a professional experimental center and strict quality control and verification system；
•   Provide LC/MS, NMR, HPLC, chiral analysis, elemental analysis and other quality inspection reports to ensure the high purity and high quality of products；
•   The biological activity of the products has been verified by the experiments of customers in various countries；
•   A variety of top journals such as Nature, Cell, Science and pharmaceutical patents have included the scientific research results of MCE customers；
•   Our professional team tracks the latest pharmaceutical and life science research and provides you with the latest active compounds in the world；
•   It has established long-term cooperation with the world's major pharmaceutical companies and well-known scientific research institutions。

MedChemExpress - Model Lupeol acetate -1617-68-1

MCE products for research use only. We do not sell...

Lupeol acetate