MedChemExpress - Model Odronextamab -1801338-64-6
Odronextamab is a stable humanized IgG4 CD20 × CD3 bispecific antibody that binds to CD3 on T cells and CD20 on B cells, triggering anti-tumor activity. Odronextamab is expected to be used in oncology research[1].MCE products for research use only. We do not sell to patients.
Odronextamab
MCE China:Odronextamab
Brand:MedChemExpress (MCE)
Cat. No.HY-P99038
CAS:1801338-64-6
Purity:99.50%
Storage:Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping:Shipping with dry ice.
Description:Odronextamab is a stable humanized IgG4 CD20 × CD3 bispecific antibody that binds to CD3 on T cells and CD20 on B cells, triggering anti-tumor activity. Odronextamab is expected to be used in oncology research.
In Vitro:Odronextamab (1-10 nM, 48-96 h) at a low picomolar concentration, mediates cytotoxicity of all tested CD20-expressing lymphoma cells[2].
In Vivo:Odronextamab (0.4-1 mg/kg, administered via intraperitoneal injection, single dose) exhibits dose-dependent tumor-suppressive activity in a mouse tumor model[2].
Species:Bispecific
Isotype:Human IgG4 kappa
Recommend Isotype Controls:Human IgG4 (S228P) kappa, Isotype Control
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References:
[1]. Rajat Bannerji, et al. Odronextamab, a human CD20×CD3 bispecific antibody in patients with CD20-positive B-cell malignancies (ELM-1): results from the relapsed or refractory non-Hodgkin lymphoma cohort in a single-arm, multicentre, phase 1 trial. Lancet H [Content Brief]
[2]. Zhu M, et al. Translational findings for odronextamab: From preclinical research to a first-in-human study in patients with CD20+ B-cell malignancies. Clin Transl Sci. 2022 Apr;15(4):954-966. [Content Brief]
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