MedChemExpress - Model Eleutheroside E -39432-56-9
Eleutheroside E is an important component of ginseng that can be taken orally. Eleutheroside E has anti-inflammatory and antioxidant properties, and it helps reduce apoptosis in heart cells caused by hypoxia-reoxygenation (H/R) damage. Eleutheroside E can improve type 2 diabetes, enhance cognitive function, and has neuroprotective effects[1][2][3][4].MCE products for research use only. We do not sell to patients.
Eleutheroside E
MCE China：Eleutheroside E
Brand：MedChemExpress (MCE)
Cat. No.HY-N0272
CAS：39432-56-9
Purity：99.58%
Storage：Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Shipping：Room temperature in continental US; may vary elsewhere.
Description：Eleutheroside E is an important component of ginseng that can be taken orally. Eleutheroside E has anti-inflammatory and antioxidant properties, and it helps reduce apoptosis in heart cells caused by hypoxia-reoxygenation (H/R) damage. Eleutheroside E can improve type 2 diabetes, enhance cognitive function, and has neuroprotective effects.
In Vitro：Eleutheroside E (10 μM, 24 h) increases insulin-induced glucose uptake in C2C12 myotubes and improves the inhibition of glucose uptake by TNF-α in 3T3-L1 adipocytes[1]. Eleutheroside E (0-100 μM, 3 h) enhances cell viability in H9c2 cells subjected to H/R injury[2]. Eleutheroside E (0-100 μM, 12 h) has a protective effect against apoptosis in H9c2 cells induced by H/R injury[2]. Eleutheroside E (100 μM, 12 h) boosts antioxidant capacity in H9c2 cells[2]. Eleutheroside E (100 μM, 12 h) blocks the MAPK pathway and inhibits the activation of NF-κB[2].
In Vivo：Eleutheroside E (0.003%, oral, daily, for five weeks) improves liver glucose metabolism in obese type 2 diabetes mice by upregulating glycolysis and downregulating gluconeogenesis[1]. Eleutheroside E (15-60 mg/kg, oral, once daily, three weeks) alleviates arthritis in a collagen-induced arthritis mouse model[3]. Eleutheroside E (50 mg/kg, oral, once daily, four weeks) prevents cognitive deficits caused by radiation in mice[4].
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References：
[3]. Wang S, et al. Eleutheroside E decreases oxidative stress and NF-κB activation and reprograms the metabolic response against hypoxia-reoxygenation injury in H9c2 cells. Int Immunopharmacol. 2020 Jul;84:106513. [Content Brief]
[4]. Chen Song, et al. Eleutheroside E supplementation prevents radiation-induced cognitive impairment and activates PKA signaling via gut microbiota. Commun Biol. 2022 Jul 8;5(1):680. [Content Brief]
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