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Hypocrellin A

MCE China：Hypocrellin A

Brand：MedChemExpress (MCE)

Cat. No.HY-N2575

CAS：77029-83-5

Purity：99.73%

Storage：4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Hypocrellin A is a PKC inhibitor that exerts antidiabetic activity by reversing the effects of high glucose on endothelin (ET-1) expression. Hypocrellin A is also a photosensitizer for photodynamic therapy (PDT) with anticancer, antibacterial and antiviral activities, especially against human immunodeficiency virus (HIV). In addition, Hypocrellin-A also possesses anti-Leishmania activity (IC50=0.27 μg/ml).

In Vitro：Hypocrellin A (150 nM; 24 h) significantly reduces the release of VEGF and ET-1 from human umbilical vein endothelial cells (HUVECs) incubated in glucose (20 mM)[1]. Hypocrellin A shows good activity against Candida albicans (IC50=0.65 μg/ml) and moderates activity against Staphylococcus aureus, MRSA, Pseudomonas aeruginosa, and Mycobacterium intracellularis[4]. Hypocrellin A (0.055-5.5 µM) loses the infectivity of both HIV-1 and VSV in a concentration-dependent manner when treats with 1 J/cm2 white light[5]. Hypocrellin A (5 µM; 6 h) increases the secretion of multiple anti-angiogenic factors in LN229 glioma, U937 macrophages and SVHCEC endothelial cells after photochemotherapy[6]. Hypocrellin A (0.25-1 µM; 48 h) has a negative impact on cell viability, migration, invasion and apoptosis of three non-small cell lung cancer cells, H460, PC-9 and H1975[8].

In Vivo：Hypocrellin A (2.5 and 5 mg/kg; i.p.; once every two days for fourteen days) inhibits tumor growth in a non-small cell lung cancer xenograft model mouse model[8].

IC50 & Target：Leishmania

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References：

[1]. Dang L, et al. Effects of hypocrellin A on expression of vascular endothelial growth factor and endothelin-1 in human umbilical endothelial cells. Am J Chin Med. 2007;35(4):713-23.  [Content Brief]

[2]. Ma YJ, et al. Enhanced Production of Hypocrellin A in Submerged Cultures of Shiraia bambusicola by Red Light. Photochem Photobiol. 2019 May;95(3):812-822.  [Content Brief]

[3]. Fehr MJ, et al. Roles of oxygen and photoinduced acidification in the light-dependent antiviral activity of hypocrellin A. Biochemistry. 1995 Dec 5;34(48):15845-8.  [Content Brief]

[4]. Ma G, et al. Antimicrobial and antileishmanial activities of hypocrellins A and B. Antimicrob Agents Chemother. 2004 Nov;48(11):4450-2.  [Content Brief]

[5]. Hirayama, et al. "Photoinactivation of virus infectivity by hypocrellin A." Photochemistry and photobiology 66.5 (1997): 697-700.  [Content Brief]

[6]. Deininger, et al. "Release of regulators of angiogenesis following Hypocrellin-A and-B photodynamic therapy of human brain tumor cells." Biochemical and Biophysical Research Communications 298.4 (2002): 520-530.  [Content Brief]

[7]. Yujie, et al. "Photodynamic antimicrobial activity of hypocrellin A." Journal of Photochemistry and Photobiology B: Biology 103.1 (2011): 29-34.  [Content Brief]

[8]. Yang, et al. "Hypocrellin A exerts antitumor effects by inhibiting the FGFR1 signaling pathway in non-small cell lung cancer." Phytomedicine 97 (2022): 153924.  [Content Brief]

[9]. Guo, et al. "Evaluation of hypocrellin A-loaded lipase sensitive polymer micelles for intervening methicillin-resistant Staphylococcus Aureus antibiotic-resistant bacterial infection." Materials Science and Engineering: C 106 (2020): 110230.  [Content Brief]