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Ionpath - Model 150Nd -Arginase-1 Antibody
Background:Arginase-1 is expressed by liver cells, myeloid-derived suppressor cells (MDSCs), macrophages, and neutrophils. In mammals, there are three enzymes that metabolise arginine: two arginase isoforms (ARG1, ARG2) and inducible nitric oxide synthase (iNOS). Arginase-1 catalyzes the breakdown of L-arginine into L-ornithine and urea as the final step in the urea cycle. L-arginine is a necessary metabolite for T cell receptor signaling and T cell proliferation. Arginase is induced by inflammation. In cancer, MDSCs within the tumor microenvironment (TME) produce arginase-1 resulting in low levels of available L-arginine within the TME leading to attenuated T cell responsiveness.
- Catalog: 715001
- Clone: EPR6672(B)
- Isotype: Rabbit IgG
- Reactivity: Human*
- Storage: Arginase-1 antibody is supplied in antibody stabilizer with 0.05% sodium azide. Store at 4°C
Validation: Each lot of conjugated arginase-1 antibody is quality control tested by MIBIscope™ analysis of stained tissue microarray using the appropriate positive and negative tissue field of views and are pathologist verified.
Recommended Usage: 1 uL of Arginase-1 antibody per 100 uL staining volume using the MIBI™ Staining Protocol.
For optimal results, antibody should be titrated for each desired application. Suggested starting range is 1:100.
MIBI technology: Learn more about MIBI™ Technology, a multiplex IHC technology with unmatched sensitivity and true subcellular resolution.