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Cytotoxic Drug Equipment & Supplies
27 equipment items found
Manufactured by:Envair Technology based inHeywood, UNITED KINGDOM
Envair Technology's CDC F Negative Pressure Isolator is designed to safeguard pharmacy and laboratory professionals from hazardous exposure to cytotoxic drugs while ensuring microbiological contamination prevention. It provides versatility with options for two or four glove configurations and customizable working areas, enhancing operational ease. These isolators ...
Manufactured by:Mablink Bioscience based inLyon, FRANCE
Most of the challenges of ADCs are linked to the hydrophobicity of the cytotoxic drugs used, which degrade the pharmacological properties of the antibody when attached to ...
Manufactured by:Mersana Therapeutics based inCambridge, MASSACHUSETTS (USA)
Once ADCs release their cytotoxic payload into targeted cells, the drug is often able to cross cell membranes, entering and potentially killing neighboring cells whether those cells are cancerous or not. This effect is called bystander-killing, which is advantageous when bystander cells are cancerous but toxic if the cytotoxic ...
Manufactured by:BioQ Pharma based inSan Francisco, CALIFORNIA (USA)
invenious connect-and-go technology is already being used to deliver infusibles in a patented range of infusion systems. Our products are thoughtfully-designed to each drug – with bespoke solutions for: Drugs requiring complex weight-based dosing. Cytotoxic drugs. Drugs that need to be reconstituted or ...
Manufactured by:Haemopharm Healthcare S.r.l. based inMilano, ITALY
The toxic effects of antineoplastic drugs used for cancer treatment, beyond the patient safety concerns, bring the occupational risks to health care workers handling hazardous drugs in the course of their duties. Multiple international studies(1) have documented, that healthcare workers who handle cytotoxic drugs have an ...
Manufactured by:Mablink Bioscience based inLyon, FRANCE
Antibody–drug conjugates (ADCs) are a unique class of targeted immuno-oncology therapeutics that combine the tumor-targeting selectivity, stability, and favorable pharmacokinetic profile of monoclonal antibodies, with the potent antitumor activity of cytotoxic drugs. ...
by:Genmab A/S based inCopenhagen V, DENMARK
Tisotumab Vedotin is an antibody-drug conjugate (ADC) targeted to tissue factor (TF), a protein involved in tumor signaling and angiogenesis.1 It is composed of Genmab’s human monoclonal antibody (mAb) that binds to TF and Seagen’s ADC technology that utilizes a cleavable linker and the cytotoxic drug monomethyl auristatin E (MMAE).1 ...
by:CIS Pharma AG based inBubendorf, SWITZERLAND
CIS Pharma develops novel antibody-drug- conjugates (ADCs) based on our proprietary polymer carrier platform. Our polymers serve as carriers that are loaded with cytotoxic drugs, radioisotopes or other active entities. The carrier together with its cargo is conjugated to a target-specific antibody using site-directed linker chemistry, different ...
Manufactured by:CytomX Therapeutics, Inc. based inSouth San Francisco, CALIFORNIA (USA)
CytomX is developing CX-2009, a Probody drug conjugate (PDC) conjugated with DM4, a highly potent cytotoxic drug, targeting CD166, also known as ALCAM. CD166 is a molecule widely and highly expressed on solid tumor cells and previously considered “undruggable” given its expression on normal tissues. In preclinical studies, Probody ...
Manufactured by:Haemopharm Healthcare S.r.l. based inMilano, ITALY
CSTD CSTD Refill® KIT, is the latest generation of systems for the reconstitution and administration of drugs, which consists of the combination of a dedicated bag and one or more Refill connectors for each vial to be reconstituted. In the common clinical practice of drug reconstitution, healthcare professionals perform a multi-step procedure that exposes ...
Manufactured by:MedChemExpress LLC (MCE) based inMonmouth Junction, NEW JERSEY (USA)
Flucytosine (5-Fluorocytosine) is an antifungal compound with oral activity. Flucytosine is a widely used cytotoxic drug that, after further metabolism, produces fluorinated ribonucleotides and deoxyribonucleotides, inhibits DNA and protein synthesis, and has multiple effects such as inhibiting candida and candida neoplasm infection and producies ...
by:LIXTE Biotechnology Holdings, Inc. based inPasadena, CALIFORNIA (USA)
Pre-clinical studies showed that LB-100 alone inhibits a spectrum of human cancers but when combined with standard cytotoxic drugs and/or radiation, LB-100 potentiates their effectiveness against hematologic and solid tumor cancers without enhancing toxicity. In addition, given at very low doses in animal models of cancer, LB-100 markedly increased the ...
Manufactured by:Mersana Therapeutics based inCambridge, MASSACHUSETTS (USA)
Immunosynthen is our novel immunostimulatory ADC platform designed to take ADCs beyond traditional cytotoxic drugs to targeted stimulation of the innate immune system. Through the safe and efficient delivery of a novel immunomodulatory STING agonist, ADCs created with our Immunosynthen platform have the potential to address the challenges of efficacy, delivery ...
by:Taiwan Liposome Company, Ltd. (TLC) based inNangang Distric, TAIWAN
TLC is using antibodies and antibody fragments attached to lipid encapsulated drugs to develop more effective therapies in oncology. These antibody-linked nanomedicines actively target specific tissues using binding interactions between a specific antibody and a target antigen on the surface of a particular cell type. Compared with passively targeted therapies, these nanomedicines are better able ...
Manufactured by:Tecninox s.r.l. based inOriggio, ITALY
The isolator is a system that allows to handle products or carry out activities in a totally isolated way in comparison with the department or cleanroom which contains it. ISOLATOR systems produced by Tecninox allow to maintain the cleaning requirements, and sterility if needed, inside the containment rooms and, at the same time, to protect the operator and the environment from highly toxic ...
Manufactured by:Athelas Incorporated based inMountain View, CALIFORNIA (USA)
The Athelas One is our flagship point-of-care blood diagnostics device. This FDA-cleared device helps simplify and enhance the blood monitoring process for those prescribed clozapine and other immunosuppressed patients. Getting a simple, onsite finger-prick is easy, eliminates the need for a venous draw, and the device returns neutrophil and white blood cell count within minutes. ...
Manufactured by:Scancell based inOxford, UNITED KINGDOM
Glycosylation is a post-translational modification that occurs inside the cell and results in the addition of sugar motifs, “glycans”, to proteins and lipids that are, in most cases, destined for the cell surface. These glycan structures form the “glycome” and play an integral role in cell-to-cell and cell-to-matrix interactions through modulation of adhesion and cell ...
Manufactured by:MedChemExpress LLC (MCE) based inMonmouth Junction, NEW JERSEY (USA)
WDR5-0103 is a potent and selective WD repeat-containing protein 5 (WDR5) antagonist with Kd of 450 ...
Manufactured by:MedChemExpress LLC (MCE) based inMonmouth Junction, NEW JERSEY (USA)
MMAF sodium (Monomethylauristatin F sodium) is a potent tubulin polymerization inhibitor and is used as a antitumor agent. MMAF sodium (Monomethylauristatin F sodium) is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) such as Vorsetuzumab mafodotin and ...
Manufactured by:MedChemExpress LLC (MCE) based inMonmouth Junction, NEW JERSEY (USA)
Monomethyl auristatin E (MMAE; SGD-1010) is a synthetic derivative of dolastatin 10 and functions as a potent mitotic inhibitor by inhibiting tubulin polymerization. MMAE is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) to treat several different cancer ...