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Dna Structure Equipment Supplied In North America
2 equipment items found
by:Alfa Cytology based inU.S. VIRGIN ISLANDS
CM03 is a potent ligand for DNA G-quadruplexes (G4s). CM03 stabilizes G4, downregulates more G4-containing genes, and increases the incidence of double-strand break events (DSBs) due to torsional strains on DNA and chromatin structures. CM03 has selective potency against pancreatic cancer cells. ...
Manufactured by:Qualigen Therapeutics, Inc. based inCarlsbad, CALIFORNIA (USA)
Stephen Neidle and his group at UCL, the G4 binding concept is derived from 30+ years in nucleic acid research, including that of G4s, which are higher order DNA and RNA structures formed by sequences containing guanine-rich repeats. G4s are overrepresented in telomeres as well as promoter sequences and untranslated regions of many oncogenes. Their prevalence is ...