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Metabolic Stability Equipment Supplied In Usa
14 equipment items found
Premium
Manufactured by:AB Sciex LLC based inFramingham, MASSACHUSETTS (USA)
Biotransformation studies are necessary for both small and large molecule therapeutics. From fast and efficient metabolic stability and soft spot analysis to in-depth, comprehensive identification of metabolites and catabolites in a sample, SCIEX offers an integrated solution to give you confident answers ...
Manufactured by:Creative Peptides based inNew York, NEW YORK (USA)
Vapreotide is a somatostatin analog with a higher metabolic stability than the parent hormone. Vapreotide reduces splanchnic blood flow, inhibits growth hormone release, and inhibits the release of peptides and vasoactive compounds from neuroendocrine tumors.http://www.creative-peptides.com/product/vapreotide-acetate-item-10-101-44-118.html ...
Manufactured by:Alfa Chemistry based inNY, NEW YORK (USA)
Introducing fluorine atom(s) into bioactive organic compounds has become a leading strategy for drug design and lead optimization. In drug synthesis strategy, fluorine is frequently employed to modify biologically relevant properties such as metabolic stability, basicity, lipophilicity and bioavailability. Additionally, the binding affinity of compounds to ...
Manufactured by:Alfa Chemistry based inNY, NEW YORK (USA)
The introduction of a fluorine atom can modulate the properties of a bioactive molecule, which may lead to changes in solubility, lipophilicity, metabolic stability, conformation, hydrogen-bonding ability and chemical reactivity. Within the various fluorinated compounds, fluorinated alkenyl is of particular interest. It is not surprising to find a number of ...
Manufactured by:AnaBios Corporation based inSan Diego, CALIFORNIA (USA)
AnaBios primary human hepatocytes are isolated from donated human livers. All donated human organs and tissue have been ethically consented for research. Primary human cryopreserved hepatocytes are ideal for many scientific applications, including toxicity, metabolism, disease modeling, genomics, enzyme-mediated mechanisms, uptake, intrinsic clearance and more. When plated, human hepatocytes from ...
Manufactured by:MedChemExpress LLC (MCE) based inMonmouth Junction, NEW JERSEY (USA)
N,N-didesmethyl AH 7921 is structurally categorized as an opioid metabolite and is a metabolite of AH ...
Manufactured by:MedChemExpress LLC (MCE) based inMonmouth Junction, NEW JERSEY (USA)
ACT-660602 is an orally active antagonist of chemokine receptor (CXCR3) with an IC50 value of 204 nM. ACT-660602 inhibits T-cell migration and shows efficacy in acute lung ingury model. ACT-660602 can be used for autoimmune diseases ...
Manufactured by:MedChemExpress LLC (MCE) based inMonmouth Junction, NEW JERSEY (USA)
MTOB sodium is a potent C-terminal binding protein (CtBP) inhibitor. MTOB sodium attenuates repetitive head injury-elicited neurologic dysfunction and neuroinflammation via inhibition of the transactivation activity of CtBP1 and CtBP2. MTOB sodium antagonizes the transcriptional regulatory activity of CtBP1 and CtBP2 by eviction from their target promoters in breast cancer cell ...
Distributed by:Optimum Therapeutic Solutions based inIrving, TEXAS (USA)
ResverActive provides a complete bioflavonoid complex with resveratrol, quercetin, and pterostilbene. These three antioxidants work together synergistically. Pterostilbene, a new focus of scientific research, is methylated resveratrol, a bio-optimized form that complements resveratrol and quercetin. These compounds are being extensively studied in the areas of cardiovascular health and ...
Manufactured by:MedChemExpress LLC (MCE) based inMonmouth Junction, NEW JERSEY (USA)
Ceritinib (LDK378) is a selective, orally bioavailable, and ATP-competitive ALK tyrosine kinase inhibitor with an IC50 of 200 pM. Ceritinib (LDK378) also inhibits IGF-1R, InsR, and STK22D with IC50 values of 8, 7, and 23 nM, respectively. Ceritinib (LDK378) shows great antitumor ...
Manufactured by:MedChemExpress LLC (MCE) based inMonmouth Junction, NEW JERSEY (USA)
BMS-963272 is an orally active and selective MGAT2 inhibitor (IC50 = 7.1 nM), used for the study of metabolic disorders and inflammatory ...
Manufactured by:MedChemExpress LLC (MCE) based inMonmouth Junction, NEW JERSEY (USA)
UMI-77 is a selective Mcl-1 inhibitor, which shows high binding affinity to Mcl-1 (IC50=0.31 μM). UMI-77 binds to the BH3 binding groove of Mcl-1 with Ki of 490 nM, showing selectivity over other members of anti-apoptotic Bcl-2 ...
Manufactured by:MedChemExpress LLC (MCE) based inMonmouth Junction, NEW JERSEY (USA)
Dihydroergotoxine mesylate (Ergoloid mesylates) is an α-adrenergic blocking agent. Dihydroergotoxine mesylate binds with high affinity to the GABAA receptor associated Cl- channel. Dihydroergotoxine mesylate also interacts with central dopaminergic and serotonergic receptors. Dihydroergotoxine mesylate displays antiproliferative, antihypertensive and neuroprotective ...
Manufactured by:MedChemExpress LLC (MCE) based inMonmouth Junction, NEW JERSEY (USA)
Linsitinib (OSI-906) is a potent, selective and orally bioavailable dual inhibitor of the IGF-1 receptor and insulin receptor (IR) with IC50s of 35 and 75 nM, ...