Regeneus - Adipose Allogenic MSCs

These bioactive communication or signalling molecules are collectively termed ‘Secretome’. Included in the Secretome is a range of soluble proteins, growth factors, cytokines, chemokines, matrix proteins, lipids, microRNAs, and extracellular vesicles, including exosomes, which Regeneus has identified as playing major roles in repairing the inflammatory state and are the cornerstone of our technology.

MSCs ‘repurpose’ damaged and inflamed tissue

MSCs were initially proposed as therapeutic due to their differentiation capabilities. Being able to differentiate into multiple cell types, including cartilage, bone and muscle to form new tissue and replace resident damaged cells, provided an attractive therapy. However, more recently, MSCs‘ mechanism of action is attributed to their ability to deliver information to inflamed and damaged target cells without being destroyed by the immune system. This means MSCs repurpose the inflamed and damaged tissue – they alter the types of cells and the bioactive factors those cells secrete that are causing the inflammation.

MSCs do this first by “homing” to the site of injury like a beacon of light. Once at the site, MSCs interact with damaged tissue and the reactive, inflammatory molecules.

Transferring a new message of balance and restoration

MSCs respond to this inflammatory microenvironment by further secreting their own arsenal of modulatory molecules working in symphony to down regulate the harmful transmission. Attracted to inflammation, MSCs and the subsequent Secretome containing the myriad of soluble and genetic material, transfer a new message of balance and restoration.

Regeneus uses Adipose Allogeneic MSCs which are mass-produced and derived from a single donor. This is different to autologous MSCs which are manufactured as a single lot from the patient being treated.

Less invasive

Adipose tissue isn’t as invasive as other methods like Bone marrow.

Allogeneic MSCs allow Regeneus to treat hundreds of thousands of patients from a single donor, chosen by our scientists after rigorous quality control testing.

Using Allogenic MSCs, and not having to alter our donor consistently, not only provides Regeneus with the confidence of the highest-grade product we can provide, but also the patient.