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29 services found
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Leukotrienes (LTs) are a group of inflammatory lipid mediators derived from arachidonic acid (AA) via the 5-lipoxygenase (5-LOX) pathway. A characteristic feature of LTs is that they are produced by leukocytes and share a conjugated triene structure. LTs consist of cysteinylleukotrienes (CysLTs) and leukotriene B4 (LTB4). CysLTs contain a cysteine ring, whereas LTB4 is a noncysteine containing ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Protein-based macromolecular drugs, typically organic compounds with molecular weights exceeding 1000, depend on cellular biosynthesis and are also known as biologics. Compared to traditional small molecule drugs, protein drugs are characterized by their high potency, strong specificity, low toxicity, clear biological function, and conducive to clinical application. Protein drugs are the ...
by:Activation Laboratories Ltd. based inAncaster, ONTARIO (CANADA)
ActLabs Biotech scientists can assist with innovative biomarker assay development and validation. To compliment our range of immunoassays, we also offer LC-MS/MS technology that has enabled us to extend our portfolio to include more biomarkers. In addition, we have invested in the field of multiplexing, using a bead-based suspension and ...
by:SGS M-SCAN Ltd based inWokingham, UNITED KINGDOM
In collaboration with the clinical team, SGS has actively pursued innovative biomarker assay development and validation. To complement our range of immunoassays, we are now offering LC-MS/MS technology that has enabled us to extend our portfolio to include more biomarkers such as steroidal and hormonal substances in the low picogram range. We ...
Manufactured by:Cambrex Corporation based inEast Rutherford, NEW JERSEY (USA)
The Drug Metabolism and Pharmacokinetic (DMPK) scope supports pre-clinical discovery and development utilizing state-of-the-art instruments including High Resolution and LC-MS/MS. In addition, Cambrex has experience with metabolite identification (ID) from such studies. ...
Manufactured by:Proteomics International based inNedlands, Perth, AUSTRALIA
Our workflows are capable of handling varying sample types including plasma, whole blood and urine. Proteomics International’s high-throughput analytical capabilities, using state of the art LC-MS spectrometers and liquid handling robots, ensures that it is able to analyse a range of small molecule, large molecule, and peptide drugs in an automated manner, ...
by:Anresco Laboratories based inSan Francisco, CALIFORNIA (USA)
Cannabinoids are the naturally occurring chemical compounds found in cannabis that work together to produce varying psychoactive and non-psychoactive effects. In combination, they are known to act synergistically to form an ‘entourage effect’, providing benefits beyond what each individually would ordinarily ...
Distributed by:KRSS Europe B.V. based inVeenendaal, NETHERLANDS
KRSS has set up a team of Clinical Application scientists with over 60 years’ experience working in clinical laboratories. This means we can now offer clinical application support at affordable prices as well as developing new automated methods in many clinical application areas which can then be offered to our CSP customers as part of their ...
Manufactured by:MuseChem based inPaoli, PENNSYLVANIA (USA)
Antibody-drug conjugates (ADCs) are a new class of highly potent oncology therapeutics for the treatment of people with cancer. An ADC could be divided into three main structural units: the antibody; the cytotoxic agent (drug); and the linker. The antibody has high affinity for a tumor-associated antigen that has restricted or no expression on normal cells. By combining this unique targeting ...
Manufactured by:Nexelis based inSeattle, WASHINGTON (USA)
Including Pharmacokinetics and Immunogenicity. Designed to be an extension of your laboratory, Nexelis, a Q² Solutions Company, supports bioanalysis in all phases with agile assay development to validation mindset. Whether we design a custom bioanalytical assay or support a client’s technology transfer, our method development process results in an optimized assay compliant with global ...
by:Bureau Veritas North America, Inc. based inNew York, NEW YORK (USA)
What are APIS and should I Be Concerned about Them? Active pharmaceutical ingredients (APIs) are defined as any substance or a mixture of substances that when used in the production of a drug, becomes an active ingredient in the drug product. Unlike most chemical hazards in the workplace for which health effects upon exposure are incidental, the purpose of an API is to have the maximum biological ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Far-western blot is a molecular biology method based on western blot technology that can be used to detect protein-protein interactions in vitro, especially interactions that do not require the natural structure of the target ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Diacylglycerol (DAG), also known as diglyceride, consists of two fatty acid chains and a glycerol molecule. It primarily exists in two forms: 1,2-diacylglycerol and 1,3-diacylglycerol. DAG can be synthesized via the phosphatidic acid pathway in the endoplasmic reticulum by the action of phosphatidic acid phosphatase or produced during the lipolysis of triglycerides (TAG) by TAG lipase. DAG is ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Sphingolipids are fundamental structural components of cell membranes, forming lipid rafts by combining with other components. Sphingolipids are involved in regulating biological processes such as cell growth, differentiation, and apoptosis. Ceramide is the central hub of the sphingolipid pathway, including sphingomyelin, glucosylceramide, and galactosylceramide, and is mainly divided into ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Active Pharmaceutical Ingredients (APIs) are substances or mixtures employed in the production of drugs. They have pharmacological effects or directly contribute to diagnosing, treating, mitigating symptoms, controlling, or preventing diseases, in addition to influencing the structure or function of the body. ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
In eukaryotic cells, the 3' end of mRNA is often extended with a poly(A) tail, a sequence of purine nucleotides. The poly(A) tail is a long chain of adenosine nucleotides of variable length. This tail is crucial for mRNA stability, transport, and translation. The analysis of mRNA's 3' poly(A) tail is a vital technique in studying the polyadenylation at mRNA molecules' 3’ ends, with significant ...
Manufactured by:Cambrex Corporation based inEast Rutherford, NEW JERSEY (USA)
Bioanalysis with an expert perspective: At Cambrex we’ve got the tools, insight and world-class expertise to support your demanding biopharmaceutical testing needs. We work closely with biotech start-ups and established biopharma companies to evaluate the quality, purity, safety and other key attributes of candidate viral therapies and large molecules at all phases of the preclinical and ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Eicosanoid, including prostaglandin (PG), thromboxane (TX), leukotriene (LT), and lipoxin (LX), is critical signaling molecule. Prostanoid, a subset of eicosanoids, comprises PG and TX. Prostanoids are named based on the number of carbon-carbon double bonds in their molecules. Most biologically active PGs and TXs belong to the series 2 molecules with two carbon-carbon double bonds. ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Endocannabinoids are amphipathilic molecules synthesized from phospholipids in the nervous system. They are a part of the endocannabinoid system, which includes G protein-coupled receptors. The most extensively studied endocannabinoids are N-arachidonoylethanolamine (anandamide) and 2-arachidonoylglycerol ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Drug affinity responsive target stability is a label-free small molecule probe technique under chemical proteomics first proposed by Lomenick et al. in 2009, which makes it possible to track and identify target proteins whose stability changes after binding with small molecules. To date, Drug affinity responsive target stability has been a focus in tracking proteins in animals, fungi, bacteria, ...