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Drug Target Services Available In Canada Saskatchewan
62 services found
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Proteolysis targeting chimera (PROTAC) drugs offer a novel approach to disease treatment by leveraging the body's innate protein degradation pathways. In contrast to traditional small-molecule inhibitors, PROTAC drugs promote the degradation of specific proteins rather than directly inhibiting their function, thus mitigating or eliminating their ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
A key step in drug discovery is target identification—identifying "druggable" biological targets. After a target is identified, it must be validated to demonstrate the functional relationship between the target and disease phenotype while ensuring safety. The drug discovery process is lengthy and ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Drug affinity responsive target stability is a label-free small molecule probe technique under chemical proteomics first proposed by Lomenick et al. in 2009, which makes it possible to track and identify target proteins whose stability changes after binding with small molecules. To date, Drug affinity responsive ...
Manufactured by:Inovotion Sas based inLa Tronche, FRANCE
Target validation is an essential and critical phase of the drug discovery process. This is a crucial step before starting to develop a treatment based on a targeted protein that has been identified to play a role in the disease. The target protein’s role must be clearly identified before starting to develop a ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Receptors are biomolecules that can bind with hormones, neurotransmitters, drugs, or intracellular signaling molecules and are capable of inducing changes in cellular function. Receptors are categorized based on their cellular location into cell surface receptors and intracellular receptors. Each receptor typically has two active sites: one that recognizes and binds to the ligand and another ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
"Knocking out" related mammalian genes is an important method for studying gene function or its potential as a drug target, widely used in research on neurodegenerative diseases such as Alzheimer's disease, cancer, cardiovascular diseases, inflammation, or metabolic diseases. CRISPR/Cas9 is a revolutionary gene-editing technology that can precisely modify the ...
Manufactured by:Creative Biolabs based inShirley, NEW YORK (USA)
Creative Biolabs can provide custom high-quality drug target localization services for functional analysis in the process of drug discovery ...
Manufactured by:Creative Biolabs based inShirley, NEW YORK (USA)
Creative Biolabs can provide custom high-quality drug target localization services for functional analysis in the process of drug discovery ...
Manufactured by:AAT Bioquest, Inc. based inPleasanton, CALIFORNIA (USA)
In addition, AAT Bioquest has used its Readilink™ technology to offer a rapid access to a variety of antibody conjugation products with small tag molecules such as fluorescent dyes, biotin, drug targets and haptens for our customers' special ...
by:Protheragen-ING based inNEW YORK (USA)
Anti-tumor APIs are a class of drugs that inhibit or kill tumor cells in the body, which are classified as chemotherapy drugs, targeted therapy drugs, immunotherapy drugs, and hormone therapy drugs according to the mode of action. Chemotherapy API works by interfering with the cell division ...
Manufactured by:Alfa Chemistry based inNY, NEW YORK (USA)
Early studies on the properties of drugs in ADMET mainly focused on human-derived or humanized tissue functional proteins as drug targets. Combined with in vitro research techniques and computer simulation, scientists study the interaction between drugs and in vivo biophysical and biochemical barrier factors. Alfa Chemistry can ...
by:Health Technology Innovations, Inc. based inPortland, OREGON (USA)
HTI employs cryo-EM services expertise collaborating with Pharma/Biotech science expertise to enable high-resolution structure determination of drug discovery targets. Here are a few of our leading customer ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Nanoparticles (NPs) undergo interactions with serum proteins during systemic administration, which may result in the formation of protein corona (PC). Investigating the interplay between the chemical and biological properties of NPs enhances clinical translation efficiency. NPs with PC can be considered to exhibit a distinct biological ...
Manufactured by:Creative Biolabs based inShirley, NEW YORK (USA)
Any malfunction of key enzymes (mutation, overproduction, underproduction or deletion) can lead to diseases. Therefore, enzymes have long been considered as important drug targets for the treatment of major human ...
Manufactured by:CENTOGENE N.V. based inRostock, GERMANY
We work with partners to develop new disease models and new biomarkers of disease. We can also use our disease models to identify new drug targets and screen chemical compounds to identify potential new drug candidates. CENTOGENE provides companies with tools to accelerate drug discovery. From population screening studies that ...
Manufactured by:Creative Peptides based inNew York, NEW YORK (USA)
The field of bioconjugation has had a considerable impact on academic research, clinical diagnostics and the production of therapeutics. Peptides are an important type of molecules for derivatization by bioconjugation. Peptide–drug conjugates hold a promising stance in the delivery of therapeutic agents by providing distinct advantage of improving therapeutic potential of ...
Manufactured by:ACROBiosystems based inNewark, DELAWARE (USA)
Biomolecular interaction analysis is used increasingly in drug development to kinetically characterize binding events of relevant components, including drugs and targets, antibodies and antigens or any pair of interacting molecules. Based on the Biacore 8K and ForteBio Octet platforms, ACROBiosystems provides biopharmaceutical R&D customers ...
Manufactured by:Absolute Antibody Ltd based inRedcar, UNITED KINGDOM
Binding multiple epitopes with a single antibody offers several benefits. For example, one specificity may target individual molecules while another could recruit effector cells or deliver a drug to the target. Other options include dual-target bispecifics which might detect a desired cell type with much higher selectivity than a ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Many drugs target proteins that function as receptors for small-molecule ligands. These ligands bind to and alter the structures of their protein targets, thus modulating their biological activities. Key protein targets in the fields of biology and pharmaceutical research include the nuclear receptors (NRs) that belong to the ...
by:Burning Rock Biotech Limited based inGuangzhou, CHINA
Burning Rock offers integrated companion diagnostic development services for biopharma partners to streamline the co-development and commercialization of targeted drugs and respective CDx （including registration testing, clinical evaluation and finally obtain registration certificates. Our US-based lab and R&D team provide additional ...