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Drug Screening Services
27 services found
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Small molecules predominantly modulate the activity of their protein targets. The majority of approved small molecule inhibitors target intracellular kinases, which regulate cell signaling by transferring phosphate groups to target proteins. Contemporary research extensively focuses on targets implicated in protein-protein interactions, cancer metabolism, and immune ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Kinases, in simple terms, are enzymes that transfer the phosphate groups of ATP to substrates. Kinases catalyze the transfer of γ-phosphate groups of ATP to substrates, mediate most signal transduction, and regulate a variety of cellular activities, including proliferation, survival, apoptosis, metabolism, transcription, differentiation, and a wide range of other cellular processes. ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
A key step in drug discovery is target identification—identifying "druggable" biological targets. After a target is identified, it must be validated to demonstrate the functional relationship between the target and disease phenotype while ensuring safety. The drug discovery process is lengthy and costly, but good target validation increases the likelihood of developing effective drugs and ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Ion channels are made up of special proteins produced by cells, which are aggregated and embedded in the cell membrane, forming pores occupied by water molecules. These pores are the channels for water-soluble substances, which can quickly enter and exit the ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Receptors are biomolecules that can bind with hormones, neurotransmitters, drugs, or intracellular signaling molecules and are capable of inducing changes in cellular function. Receptors are categorized based on their cellular location into cell surface receptors and intracellular receptors. Each receptor typically has two active sites: one that recognizes and binds to the ligand and another ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Humans are highly organized systems comprised of approximately 3.72×1013 cells of various types, which maintain proper organ function and normal cellular homeostasis. Despite significant and revolutionary discoveries in the field of cell biology, the heterogeneity of cells still requires further investigation. Single-cell RNA sequencing (scRNA-seq) has become the latest method for revealing the ...
Manufactured by:Shared Imaging based inDowners Grove, ILLINOIS (USA)
Shared Imaging provides qualified, ARRT/ARMRIT/NMTCB/ARDMS certified technologists who will represent your facility with respect and professionalism. All staff members must pass drug screenings and background screenings and are in compliance with all federal and state requirements. Our clinical staff are carefully chosen to fit seamlessly into ...
by:Strateos Inc. based inMenlo Park, CALIFORNIA (USA)
Strateos offers a wide range of off the shelf drug discovery assays and supports custom development of biochemical, biophysical and cell based assays in drug discovery, using both industry-standard and innovative technologies to support drug screening projects from hit identification to lead ...
Manufactured by:Creative Bioarray based inShirley, NEW YORK (USA)
Immortalized cell lines and services are of ever-increasing importance in various aspects of biomedicine, toxicology and biotechnology. The cells can be used as model systems in phenotypic and drug screening, high content analysis, target identification, drug development, toxicology testing, gene editing studies, reporter assays. Besides, the ...
Manufactured by:Creative Bioarray based inShirley, NEW YORK (USA)
Immortalized cell lines and services are of ever-increasing importance in various aspects of biomedicine, toxicology and biotechnology. The cells can be used as model systems in phenotypic and drug screening, high content analysis, target identification, drug development, toxicology testing, gene editing studies, reporter assays. Besides, the ...
Manufactured by:Nal Von Minden Gmbh based inMoers, GERMANY
Nal von minden offers a wide range of tests for the detection of drugs or their consumption in urine, saliva, blood (serum, plasma) or - in the case of alcohol - in breath. More than 30 different parameters as well as 7 different adulteration parameters can be detected using our Drug Screen urine rapid tests. ...
by:Helix Diagnostics based inWaterford Twp, MICHIGAN (USA)
Why is it important to monitor abuse of controlled substances while providing the right care for your pain patients? OB/GYN using drug screening as part of their daily routine are increasing across America. American Congress of Obstetricians and Gynecologists (ACOG) recommends physicians to test their patients for illicit drugs at their first ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Drug screening refers to the evaluated process of substances (samples) potentially used as drugs, assessing their biological activity, pharmacological effects, and therapeutic value through appropriate methods. This process encompasses biochemical and cellular levels of screening, divided into high-throughput ...
by:CrystalsFirst GmbH based inMarburg, GERMANY
We also provide consulting services for the target-to-hit phase and structurally-enabled campaigns. Our cutting-edge solutions, collaborative culture, speed and agility, enable us to move with you in the direction, that will best suit your quest for success. Fragment-based drug design relies heavily on the availability of structural data for fragment growth into a lead candidate. Based on our ...
Manufactured by:Puracyp based inCarlsbad, CALIFORNIA (USA)
Screening for nuclear receptor activation is a widely used and accepted practice to predict adverse drug effects and drug-drug interactions. Moreover, assessing nuclear receptor activation meets the latest FDA guidance for industry on Drug-Drug Interactions. Receptor activation ...
by:BiomimX S.r.l. based inBresso, ITALY
uHeart is the ideal platform to screen drug cardiotoxicity as early as possible in the drug discovery pipeline. BiomimX® offers services for screening biomolecules’ cardiotoxicity on uHeart model. ...
Manufactured by:Alfa Chemistry based inNY, NEW YORK (USA)
Alfa CDMO's CRO offers custom services for research, optimization, and development phases of your project. ANTIBODY ENGINEERING CHEMICAL SYNTHESIS ANTIBODY DRUG CONJUGATION SCREENING ADC Assay and Mechanism Study Learn more: ...
Manufactured by:CD Formulation based inShirley, NEW YORK (USA)
The Main Objectives of Conducting Forced Degradation Tests Include: Resolve the degradation products and determine the degradation pathway and mechanism of the drug. Help the development of API processes, formulation prescriptions and processes, and to help the screening of drug salts and crystalline forms. Provide support for ...
Manufactured by:AAT Bioquest, Inc. based inPleasanton, CALIFORNIA (USA)
Cell based assays offer a biologically relevant substitute to predict the response of a drug on an organism and while initially used mostly for secondary screening, are now progressively being used for primary screens. AAT Bioquest offers a broad spectrum of cell-based assays for cell cytotoxicity, cell proliferation, GPCR and ion channels. ...
Manufactured by:Germaine Laboratories, Inc. based inSan Antonio, TEXAS (USA)
Our Drugs of Abuse Testing division has many years’ experience assisting major employers, School Districts, Criminal Justice and Drug Court entities throughout the United States. Our laboratory staff is dedicated to providing you with reliable results when you need ...