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Protein Targeted Services
53 services found
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Many drugs target proteins that function as receptors for small-molecule ligands. These ligands bind to and alter the structures of their protein targets, thus modulating their biological activities. Key protein targets in the fields of biology and pharmaceutical research include the nuclear ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Small molecules predominantly modulate the activity of their protein targets. The majority of approved small molecule inhibitors target intracellular kinases, which regulate cell signaling by transferring phosphate groups to target proteins. Contemporary research extensively focuses on targets ...
Manufactured by:CELONIC Group based inBasel, SWITZERLAND
Efficiency is the key for a good downstream process to obtain consistently a pure and high quality product while recovering as much target protein as possible. Celonic has set up a downstream platform process for antibodies, often recovering more than 75% of the target mAB. This saves considerable development time and costs. ...
by:Base Pair Biotechnologies, Inc. based inPearland, TEXAS (USA)
Receive one vial of Aptamer Resuspension Buffer and one vial of Aptamer Folding Buffer FREE with any Catalog Aptamer Purchase*. Base Pair offers catalog aptamers to a diverse range of target molecules, including proteins, antibodies, small molecules, toxins, bacterial proteins, cytokines, and more. Aptamers can be purchased with a wide range of ...
Manufactured by:Creative Biolabs based inShirley, NEW YORK (USA)
The drug-discovery process is a trial-and-error run and time-consuming. Currently, using in silico tools to find a molecule that binds to the target protein has made computational chemistry a valuable tool in drug ...
Manufactured by:Orbit Discovery based inOxford, UNITED KINGDOM
Engineering soluble and membrane bound proteins. Our flexible peptide display platforms allow for screening directly against both cells and recombinant target protein. The Orbit team incudes experts on structural biology and protein production to ensure the quality of target protein for affinity ...
by:SilcsBio, LLC based inBaltimore, MARYLAND (USA)
Guess work in drug discovery can be costly and time consuming. Our team is here to remove that for you. With us, your team ...
by:Cyrus Biotechnology Inc. based inSeattle, WASHINGTON (USA)
Protein design has evolved tremendously over the last 20 years and Rosetta has been at the bleeding edge throughout that time. Rosetta was first at most major protein design achievements, such as protein stabilization, affinity, enzyme specificity, novel protein assemblies, and even entirely new protein structures with no sequence similarity to natural ...
by:Ainnocence Inc. based inSacramento, CALIFORNIA (USA)
Concentrated; PharmCollectibles contains a highly selective chemical probe library for over 2,000 human target protein for efficient target identification. Representative; PharmaCollectibles condenses 14 million chemical compounds into a 50,000 compound library against a highly diverse set of ...
by:Creative Proteomics based inNew York, NEW YORK (USA)
Ubiquitin is an about 8.5 kDa polypeptide consisting of 76 amino acids that is appended to the ε-NH2 of lysine in target proteins via the C-terminal glycine of ubiquitin. Following an initial monoubiquitination event, the formation of a ubiquitin polymer may occur, and polyubiquitinated proteins are then recognized by the 26S proteasome ...
by:Reaction Biology Corp. based inMalvern, PENNSYLVANIA (USA)
Cell-based assays are valuable to probe new drug candidates in the environment of intact cells with physiologic concentrations of substrates, co-factors and ...
Manufactured by:Orbit Discovery based inOxford, UNITED KINGDOM
The result is a library of unique beads each displaying thousands of copies of peptide, providing massive chemical diversity and the ability to perform rapid screens for high affinity binders against soluble or more complex target proteins, such as GPCRs and ion ...
Manufactured by:Preclinics GmbH based inPotsdam, GERMANY
Their heavy-chain antibodies lack the light chain and therefore can be used to develop recombinant single-domain antibodies (VHH fragments) with several benefits: Small size: With a molecular weight of approximately 15 kDa, Easier production, High stability: As there is only one protein chain, correct refolding after physical stress keeps the functionality.We can immunize your ...
Manufactured by:Echelon Biosciences, Inc (EBI) based inSalt Lake City, UTAH (USA)
Nanobodies are single domain antibodies produced from camelids by immunization with a target antigen, similar to the process used in mice and rabbits for traditional antibody generation. However, because of the single heavy chain found in camelid antibodies, cDNAs can be generated from this single domain which can then be expressed recombinantly. This opens up a wide variety of applications that ...
Manufactured by:Epigentek Group Inc. based inFarmingdale, NEW YORK (USA)
Chromatin immunoprecipitation (ChIP) offers an advantageous tool for studying protein-DNA interactions and can be used to determine whether a specific protein binds to a particular sequence of a gene, such as the target sequence of a transcription factor or to compare the levels of histone methylation associated with a specific gene promoter ...
Manufactured by:Creative Bioarray based inShirley, NEW YORK (USA)
Protein kinases are involved in many cellular signaling pathways and comprise one of the largest families of homologous proteins. They play an extensive role in signal transduction and regulation of the complex cellular processes necessary to maintain life. Overexpression and/or dysregulation of protein kinases lead to a variety of diseases, thus ...
by:RASA Life Science Informatics based inPune, INDIA
How Our Protein Modelling Service / Homology modeling Service Can Help You? Rasa Bioinformatic CRO Lab offer high quality protein tertiary structures custom modeling services based on your own amino-acid sequences. Combination of modeling and short term simulations under controlled parameters will ensure the reliability of modeled structure for further studies RASA’s protein modeling ...
Manufactured by:Creative Biogene based inShirley, NEW YORK (USA)
Messenger RNA (mRNA) is responsible for transferring genetic information from DNA to proteins. With advances in in vitro transcription (IVT) technology, it has been possible to synthesize mRNA from either plasmid-based DNA templates or DNA PCR amplified from plasmids. mRNA synthesized by IVT methods could be sequence optimized to improve efficiency of translation as well as ...
Manufactured by:Creative Biolabs based inShirley, NEW YORK (USA)
Creative Biolabs offers engineered protein scaffold library construction service. Our service has provided a strong foundation for the successful isolation and exploitation of high-affinity binders in the fields of research, diagnosis, and therapy. Creative Biolabs has developed trimer codon technology, which offers site-directed mutant library construction in a high-throughput and extremely ...
Manufactured by:Creative Biostructure based inShirley, NEW YORK (USA)
The formation of virus-like particles (VLPs) is a result of self-assembly of one or several types of viral structural proteins, such as Envelope or Capsid. The component proteins can originate from different viruses or be recombinantly expressed. Various systems have been used in the successful construction of VLPs from different sources including bacterial, yeast, insect cells, plant and ...