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Cell Culture Services In Usa Massachusetts
18 services found
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
In biopharmaceutical engineering and bioproduct production, the detection and control of process-related impurities are the core of product quality management. These impurities may include cell matrix (host residual proteins, host residual DNA), cell cultures (inducers, antibiotics, or culture medium components), and by-products ...
by:Dyno Therapeutics based inWatertown, MASSACHUSETTS (USA)
Dyno’s lab provides the experimental capabilities that comprise the CapsidMap™ platform. The lab is responsible for creating novel vectors and assaying a diverse array of properties. Experiments at Dyno span pooled libraries with hundreds of thousands of AAV variants to assays focused on individual vectors. Our team rigorously employ diverse experimental approaches and innovate to ...
Manufactured by:Exosome Diagnostics, Inc. based inWaltham, MASSACHUSETTS (USA)
After marker identification, biomarkers and/or gene signatures enter our development process to become targeted assays. The newly identified biomarkers are developed into a Laboratory Developed Test (LDT) that will be run in Exosome Diagnostic’s CLIA and CAP accredited ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Cell death occurs through several pathways including apoptosis, necrosis, and other emergent pathways. Apoptosis is pivotal in immune responses, involving processes such as intracellular balance, T cell clustering, the death of reactive lymphocytes, and cytotoxity of target cells. Apoptosis involves key components like APO-1/Fas, a receptor essential for apoptotic signaling; Caspase-3, crucial ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Obesity is a systemic disease, not only does it lead to changes in body shape, but it also brings along various diseases and complications, affecting an individual's overall health. Common complications, such as hyperglycemia, hyperlipidemia, and hypertension, are medically termed as "metabolic syndrome". The fluid factors secreted by adipose tissue propel the development of metabolic syndrome ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Atopic Dermatitis (AD) is prevalent among children aged 1 to 5 years and a considerable number of patients carry this condition into adulthood. As a chronic inflammatory skin disease, AD often coexists with asthma and rhinitis. At the cellular level, the hallmark of AD is characterized by high serum IgE levels, where T cells play a crucial regulatory role. ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Cardiovascular diseases are usually associated with systemic inflammatory responses, such as increased expression of inflammatory proteins CRP, IL-1, IL-6, IL-18, and TNF-α. These proteins can be considered as diagnostic markers for the risk assessment of various cardiovascular diseases. For instance, CD40, which belongs to the tumor necrosis factor receptor superfamily, and CD40L play a crucial ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Diabetes is marked by hyperglycemia, resulting from defects in insulin secretion and action, which disturbs the metabolism of carbohydrates, fats, and proteins. Type 1 Diabetes (T1D) is an autoimmune disease where T cells mediate inflammation and specifically damage pancreatic β ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Systemic lupus erythematosus (SLE) is a classic systemic autoimmune disorder characterized by impaired autoimmune tolerance and high concentration of autoantibodies targeting self-antigens, which lead to organ damage. This pathological process involves multiple cytokines. ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Class III medical devices are medical devices that pose potential danger to the human body and require strict control to ensure their safety and effectiveness. These devices typically include implants, life-supporting or life-sustaining devices, and equipment that poses potential danger to the human ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Metabolic bone disease encompasses a range of bone disorders caused by congenital or acquired factors that disrupt normal bone metabolism and biochemical states, leading to disorders in bone biochemistry and metabolism. These disorders stem from abnormalities in three key areas: bone resorption, bone growth, and mineral deposition. Increasingly, research has identified numerous cytokines involved ...
by:TÜV SÜD America Inc. based inWakefield, MASSACHUSETTS (USA)
In the medical field, practitioners utilize a range of devices to address patient health, from diagnosis to surgery. When the patient comes into contact with a medical device or material, it should fulfill its intended function without harming the patient. Therefore, all medical devices need to undergo a thorough biological risk assessment to protect the patient from any toxic, physiological, ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Receptors are biomolecules that can bind with hormones, neurotransmitters, drugs, or intracellular signaling molecules and are capable of inducing changes in cellular function. Receptors are categorized based on their cellular location into cell surface receptors and intracellular receptors. Each receptor typically has two active sites: one that recognizes and binds to the ligand and another ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Drug screening refers to the evaluated process of substances (samples) potentially used as drugs, assessing their biological activity, pharmacological effects, and therapeutic value through appropriate methods. This process encompasses biochemical and cellular levels of screening, divided into high-throughput screening (HTS) and virtual ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
To maintain the immune system's homeostasis, multiple control systems are essential for managing infections, inhibiting tumor growth, preventing inflammation, and avoiding autoimmune diseases. T cells are known to be critical in this regulatory process. Specifically, Th3 cells primarily secrete TGF-β along with varying levels of IL-4 and IL-10. Natural regulatory T cells and Tr1 cells can ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
During the tumor formation process, cancer cells release various cytokines and growth factors into the surroundings and reprogram many other types of cells to establish a tumor microenvironment. As a result, tumor tissues almost always contain a large number of endothelial cells, fibroblasts, and infiltrating inflammatory cells, which in turn produce various cytokines. Tumor-derived VEGF acts on ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
The inauguration of monoclonal antibodies (mAbs), derived from mice, were immunogenic in humans. These molecules were first synthesized in 1975 by Georges Köhler and César Milstein through the use of hybridoma technology. Later, in 1984, another milestone was achieved with the production of chimeric human antibodies via recombinant DNA technology. Hybridoma technology facilitates the creation of ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Antibody therapies leverage human immune system antibodies to treat diseases by targeting specific proteins on pathogens or abnormal cells with exceptional precision. The development of antibody therapies has evolved from early polyclonal sera to monoclonal antibodies, and now to genetically engineered antibodies, focusing on enhancing drug safety, effectiveness, and manufacturing ...