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Neurodegenerative Diseases Services In Usa
18 services found
Manufactured by:Creative Biogene-Mitochondrial Research based inNY, NEW YORK (USA)
Neurodegenerative diseases (NDs) comprise a diverse set of pathological processes involving progressive neuronal dysfunction, degeneration, and death, leading to incurable and debilitating diseases. Creative Biogene provides a comprehensive range of services and products to assist researchers in neurodegeneration-related mitochondria ...
Manufactured by:Creative Biogene-Mitochondrial Research based inNY, NEW YORK (USA)
Creative Biogene provides the fractionated mitochondrial magnetic separation (FMMS) method to increase the production of brain-derived mitochondria compared with the UC method and can better detect mitochondrial damage in the central nervous system injury and neurodegenerative ...
Manufactured by:Creative Biolabs based inShirley, NEW YORK (USA)
Multiple Sclerosis (MS) is a chronic inflammatory neurodegenerative disease of the central nervous system (CNS). Experimental autoimmune encephalomyelitis (EAE) is the most common animal model of human MS as it is especially useful to investigate neuroinflammatory pathways and often serves as a "proof-of-principle" model for the efficacy of novel treatment ...
Manufactured by:RareStone Group based inShanghai, CHINA
Rare neurological diseases include developmental defects of the nervous system, genetic and metabolic diseases, neuroimmune diseases, neurological tumors, special types of infectious diseases of the nervous system, neurodegenerative diseases, and neuromuscular diseases. At ...
Manufactured by:Creative Biolabs based inShirley, NEW YORK (USA)
Autophagy is a key catabolic process that ensures the removal of excess or damaged cellular components under physiological and pathological conditions, and provides a metabolic supply in the absence of extracellular nutrients, thereby maintaining the proper balance of cells. Optimal autophagy activity plays an important protective role in several human diseases, such as ...
Manufactured by:Neurodigitech, LLC based inEncinitas, CALIFORNIA (USA)
The NDT teams in specialized in both non-GLP and GLP compliant pre-clinical assessments of CNS disease therapeutics using a variety of biomarkers, including histology, immunohistochemical and histochemical methods. In particular, NDT is dedicated to custom-designed neuropathological assessments for the neurodegenerative diseases, such as ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
PROTACs can not only offer potential therapeutic applications for a variety of conditions, including cancer, immune dysregulation, viral infections, and neurodegenerative ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
"Knocking out" related mammalian genes is an important method for studying gene function or its potential as a drug target, widely used in research on neurodegenerative diseases such as Alzheimer's disease, cancer, cardiovascular diseases, inflammation, or metabolic diseases. CRISPR/Cas9 is a revolutionary ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
PROTACs can not only offer potential therapeutic applications for a variety of conditions, including cancer, immune dysregulation, viral infections, and neurodegenerative diseases, but also provide a unique chemical knockdown tool for biological research in a catalytic, ...
Manufactured by:Advanced Brain Monitoring, Inc. based inCarlsbad, CALIFORNIA (USA)
Biomarker specializations include Alzheimer’s and dementia, Parkinson’s and basal ganglia disorders, mood disorders and other neurodegenerative and neuropsychiatric diseases. ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Gangliosides are a large class of complex lipids that are abundant in the neuronal cell membranes in the brain. These molecules consist of sphingolipids with one or more sialic acids attached to the sugar chain. As structural components of cell membranes, gangliosides have their two hydrocarbon chains embedded in the plasma membrane, while the oligosaccharides are located on the cell surface, ...
Manufactured by:Ozgene Pty Ltd. based inBentley DC, AUSTRALIA
Knockout mice are animal models that have been genetically modified to delete or inactivate a specific gene. The term ‘knockout’ refers to knocking out the functionality of the target gene. These mouse models allow researchers to gain insight into how the loss of the gene affects physiology, behavior and disease development. Observing the characteristics of a knockout phenotype can ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Cerebrospinal fluid (CSF) is secreted within the central nervous system (CNS) and fills in the ventricles, the subarachnoid space of the brain, and the spinal column. CSF's role is to protect the brain from physical impacts. Furthermore, CSF plays a crucial role in the circulation of nutrients and chemicals in the blood and in waste management by actively transporting or facilitating bulk flow ...
Manufactured by:Arthus Biosystems, LLC based inChantilly, VIRGINIA (USA)
SAM analog and antibody: One of the important S-adenosylmethionine (SAM) analogs has a very good thermostability and yet a high hygroscopicity. This analog can also be used as a standard in in intro assays of ...
Manufactured by:Arthus Biosystems, LLC based inChantilly, VIRGINIA (USA)
S-adenosylmethionine (SAM) is an important molecule in methionine cycle pathway and one carbon metabolism pathway that are implicated in many metabolic abnomalities found in humans. Methylation index is defined as the ratio of SAM and SAH, which is a better way to evaluate methylation status of humans and other organisms. The level of S-adenosylmethionine (SAM) fluctuates depending on age, ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Prostanoids, also known as eicosanoids, are a family of signaling molecules produced and secreted by various types of cells under both normal and pathological conditions. In the human body, these metabolites are excreted into body fluids such as plasma and urine. The precursors of prostanoids are 20-carbon polyunsaturated fatty acids (PUFAs) like arachidonic acid (C20:4), which are esterified in ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Proteolysis targeting chimera (PROTAC) drugs offer a novel approach to disease treatment by leveraging the body's innate protein degradation pathways. In contrast to traditional small-molecule inhibitors, PROTAC drugs promote the degradation of specific proteins rather than directly inhibiting their function, thus mitigating or eliminating their role in disease progression. ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Proteins play a pivotal role in the regulation, function, and structure of various human organs and tissues. The regulation of the synthesis and degradation of proteins is crucial for cell functionality. Protein turnover can exist in three states: equilibrium, pool expansion, and pool contraction. At equilibrium, the rate of protein synthesis matches that of degradation, leading to unchanged ...