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Proteomics Services In Usa
88 services found
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
With ongoing advancements in proteomics mass spectrometry technology, there has been a notable increase in the precision of analytical instruments, resulting in a richer dataset. While this detailed protein data is invaluable for deeper scientific investigation, the vast volumes of data produced by high-throughput proteomic screenings introduce substantial ...
by:Ionpath, Inc. based inMenlo Park, CALIFORNIA (USA)
Spatial Proteomic Services projects for human FFPE tissue begin with one of the following panels. Additional add-on markers are available to meet the needs of the project, and Ionpath routinely performs custom antibody validation for new markers of ...
by:Nautilus Biotechnology based inSeattle, WASHINGTON (USA)
As we begin to scratch the surface of the true complexity and nuance of human health and disease, a breakthrough increase in proteomics analysis throughput will allow researchers to measure at the scale needed to power the studies needed to quickly and cost effectively discover these new diagnostic ...
Manufactured by:Profacgen based inShirley, NEW YORK (USA)
Ubiquitylation is one of the most prevalent post-translational modifications (PTM) within cells. Ubiquitin modification induces protein degradation, which effect on protein function, localization and activity. Therefore, the study of protein ubiquitination plays an important role in cell biology and drug discovery. As a professional PROTAC services provider, Profacgen offers various ubiquitin ...
by:Nautilus Biotechnology based inSeattle, WASHINGTON (USA)
At Nautilus, our philosophy is to engage with the broader scientific community and utilize our technology and expertise to enable novel, high impact, proteomic discoveries. We are now providing access to our technology for a select group of collaborators. Currently, we are exploring research across a wide range of fields, including oncology, neuroscience, infectious disease, ...
by:Creative Proteomics based inNew York, NEW YORK (USA)
Gene ontology, GO for short, is a quite powerful bioinformatics initiative to unify the representation of gene and gene product attributes across all species. Gene Ontology is established by Gene Ontology Consortium in 2008 in order to annotate and classify genes and their corresponding products, mainly under 3 terms: molecular functions, cellular components and biological processes. More ...
by:Creative Proteomics based inNew York, NEW YORK (USA)
The purpose, is to discover a system of organizing observations, usually genes, and proteins into groups, where members of the groups share properties in common. In Creative Proteomics, we can interpret the data you collected with a set of typical clustering methodologies, algorithms, and applications, which include partitioning methods such as k-means, hierarchical methods and ...
Manufactured by:Creative Biogene-Mitochondrial Research based inNY, NEW YORK (USA)
Creative Biogene is committed to mitochondrial research, providing global customers with mitochondrial genomics services, mitochondrial proteomics services, and other custom mitochondrial research services. We have advanced platforms, equipment, a team of experts with rich experience, and standard system processes to offer state-of-the-art mitochondrial custom services to our ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Proteolysis targeting chimera (PROTAC) drugs offer a novel approach to disease treatment by leveraging the body's innate protein degradation pathways. In contrast to traditional small-molecule inhibitors, PROTAC drugs promote the degradation of specific proteins rather than directly inhibiting their function, thus mitigating or eliminating their role in disease progression. ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Antibodies bind to various antigens with high affinity and specificity, playing a crucial role in adaptive immune response to infections and can also mediate autoimmune diseases by targeting self-antigens. Antibodies facilitate immunity by inhibiting critical stages of a pathogen's replication cycle, such as receptor binding and cellular entry, activating the complement system, or initiating ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Protein-based macromolecular drugs, typically organic compounds with molecular weights exceeding 1000, depend on cellular biosynthesis and are also known as biologics. Compared to traditional small molecule drugs, protein drugs are characterized by their high potency, strong specificity, low toxicity, clear biological function, and conducive to clinical application. Protein drugs are the ...
by:Creative Proteomics based inNew York, NEW YORK (USA)
KEGG, abbreviation of Kyoto Encyclopedia of Genes and Genomes, is a collection of databases, which is used for bioinformatics research, including data mining in genomics, proteomics, metabolomics and other omics studies, modeling and simulation in systems biology, and translational research in drug R & ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
PROTACs represent a novel strategy for protein degradation that has gained prominence recently. Utilizing bifunctional molecules, PROTACs enable the targeted ubiquitination and subsequent degradation of proteins via the UPS. PROTACs can not only offer potential therapeutic applications for a variety of conditions, including cancer, immune dysregulation, viral infections, and neurodegenerative ...
by:Creative Proteomics based inNew York, NEW YORK (USA)
This is achievedby using analytical technologies such as NMR and mass spectrometry combined with sophisticated statistical methods to interpret the generated data. Compared with genomics, transcriptomics and proteomics, metabolomics provide a direct and global snapshot of all the metabolites, and tell the researchers what have happened, making it more and more popular in disease ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Compared with genetic biomarkers, protein biomarkers provide higher degrees of differential information. Olink proteomics is based on a unique proximity extension assay (PEA) technique that enables simultaneous quantification of multiple protein ...
by:Creative Proteomics based inNew York, NEW YORK (USA)
Nitric oxide (NO) is produced by three isoforms of nitric oxide synthase (NOS) and is a chemical messenger that reacts with free cysteine residues to form S-nitrothiols (SNOs). S-nitrosylation is a critical PTM used by cells to stabilize proteins, regulate gene expression and provide NO donors, and the generation, localization, activation and catabolism of SNOs are tightly ...
by:Creative Proteomics based inNew York, NEW YORK (USA)
Proteins are vital macromolecules, the workhorses that facilitate most biological processes at both cellular and systemic levels, but they rarely act alone. Lots of essential molecular processes are carried out by molecular machines that are based on a large number of protein components organized by their Protein-Protein Interactions(PPIs), which refer to intentional physical contacts established ...
by:Creative Proteomics based inNew York, NEW YORK (USA)
Protein phosphorylation is the most commonly studied area of post-translational modification since it plays a vital role in intracellular signal transduction and is involved in regulating cell cycle progression, differentiation, transformation, development, peptide hormone response, and adaptation. It has been estimated that one third of mammalian proteins may be phosphorylated and this ...
by:Creative Proteomics based inNew York, NEW YORK (USA)
Ubiquitin is an about 8.5 kDa polypeptide consisting of 76 amino acids that is appended to the ε-NH2 of lysine in target proteins via the C-terminal glycine of ubiquitin. Following an initial monoubiquitination event, the formation of a ubiquitin polymer may occur, and polyubiquitinated proteins are then recognized by the 26S proteasome that catalyzes the degradation of the ubiquitinated ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Drug affinity responsive target stability is a label-free small molecule probe technique under chemical proteomics first proposed by Lomenick et al. in 2009, which makes it possible to track and identify target proteins whose stability changes after binding with small molecules. To date, Drug affinity responsive target stability has been a focus in tracking proteins in animals, ...
