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Brain Axis Therapeutic Product Applications In Europe
4 applications found
The delivery of therapeutical compounds such as RNA drugs into the brain presents the challenges of RNA preservation and the crossing of the blood brain barrier. Exosomes loaded with the specific siRNA sequences and marked with the neuron specific RVG peptide show specific accumulation in neurons, microglia and oligodendrocytes in the brain, effectively reducing genetic expression. This is a potential approach for brain diseases like Alzheimer, while reducing side effects due to unspecific tissue ...
ByNanovex Biotechnologies based in Llanera, SPAIN
The trespassing of the blood brain barrier is a challenge for the treatment of central nervous diseases such as Alzheimer, Parkinson, stroke, or cancer (glioma). The endothelium shows tight junctions and specialized transporters which limits the bioavailability of drugs in the central nervous ...
ByNanovex Biotechnologies based in Llanera, SPAIN
Functional ultrasound (fUS) imaging is emerging as a powerful tool in neuropharmacology to study the effects of drugs on brain activity. Unlike fMRI, fUS offers increased sensitivity and compatibility with awake animal models, providing an unbiased view of drug interactions with neural substrates. Recent studies by Theranexus have utilized fUS to observe the hemodynamic response to different pharmacological interventions, such as the combination of donepezil and mefloquine, which target acetylcholinesterase ...
ByIconeus based in Paris, FRANCE
At Nexstim we are using decades of scientific research to help alleviate drug-resistant brain diseases and disorders. As the world’s leading company combining TMS with 3D brain imaging, we offer a powerful noninvasive technique for the relief of chronic, refractory neuropathic ...
ByNexstim Plc based in Helsinki, FINLAND