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Alzheimer Articles & Analysis
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Dysregulation of ubiquitination is a hallmark of numerous human diseases, including many cancers, neurodegenerative disorders like Parkinson's and Alzheimer's, and autoimmune conditions. How We Study the 'Ubiquitome': Ubiquitinated Proteomics Analysis Given its central role in health and disease, understanding which proteins are ubiquitinated, when, and how, is a major goal for ...
One notable study published in Nature Neuroscience (2021) demonstrated how CX3CL1-fractalkine signaling influences microglial activity in neurodegenerative diseases like Alzheimer’s. These findings suggest potential avenues for therapeutic intervention targeting neuroinflammation. ...
Neuroscience: Explore the role of inflammation and growth factors in neurodegenerative diseases like Alzheimer’s. Clinical Diagnostics: Develop biomarkers for disease progression, response monitoring, or precision medicine strategies. ...
Metabolic Health and Disease Research Alterations in NAD/NADH levels are associated with a wide range of diseases, including cancer, diabetes, neurodegenerative disorders (e.g., Alzheimer’s and Parkinson’s), and mitochondrial diseases. Measuring NAD/NADH ratios can reveal metabolic dysfunctions. ...
This opens new avenues for treating central nervous system disorders, such as Alzheimer's and Parkinson's disease, and expands the potential of drug candidates. ...
PEGylated nano-carriers, such as micelles and dendrimers, can traverse the BBB more effectively, offering new therapeutic options for treating CNS disorders like Alzheimer's disease and brain tumors. The applications of PEG derivatives in pharmaceuticals and drug delivery illustrate their profound impact on modern medicine. ...
In the nervous system, abnormal TNC protein levels have been linked to neurodegenerative diseases like Alzheimer's and Parkinson's. Research suggests it may influence the deposition of harmful protein aggregates that are a hallmark of these disorders. ...
In certain neurodegenerative diseases, such as Alzheimer's disease (AD), Tau protein may undergo abnormal phosphorylation and aggregation, forming so-called Tau tangles or neurofibrillary tangles.Ubiquitination is a kind of post-translational modification of proteins, involving the linkage of one or more ubiquitin molecules to the target protein. ...
Do you have fragmented sleep all through the night? Do you wake up oftentimes at night, struggling to breathe? Is your partner tired of your heavy snoring and often reminds you to see a doctor? Well, if your chronic, frequent snoring is associated with sleep apnea, there are a number of factors and issues to be aware of. Basically, it’s a matter of cause and effect with sleep apnea ...
MMP-9 has also been proposed as a therapeutic target for Alzheimer's disease and type 2 diabetes. Neuronal MMP-9 is involved in synaptic plasticity by controlling the shape of dendritic spines and the function of excitatory synapses, thus playing a key role in learning, memory and cortical plasticity. ...
Imagine a world where diseases like cancer, Alzheimer's, and Parkinson's could be diagnosed and treated at the molecular level, long before symptoms even appear. ...
ByMatexcel
Other Disease Models Apart from COPD, disease models are integral to understanding and managing several other illnesses. For example, In Alzheimer's, transgenic mouse models provided essential insights into disease mechanisms. Alzheimer's disease modelling has moved from simple organisms like yeast and worms to sophisticated mouse models, each offering insights ...
They contain a range of biomolecules, such as lipids, proteins, and nucleic acids. Cancer, Alzheimer's disease, and Parkinson's disease are just a few of the illnesses for which EVs can be used as biomarkers. ...
Other Disease Models Apart from COPD, disease models are integral to understanding and managing several other illnesses. For example, In Alzheimer's, transgenic mouse models provided essential insights into disease mechanisms. Alzheimer's disease modelling has moved from simple organisms like yeast and worms to sophisticated mouse models, each offering insights ...
Neurodegenerative Diseases: Understanding the intricate relationships between drugs and neurodegenerative diseases like Alzheimer's and Parkinson's is crucial for finding effective treatments and interventions to slow disease progression. ...
Cholinesterase inhibitors play a crucial role in the treatment of Alzheimer's disease and other cognitive impairments by increasing the levels of acetylcholine in the brain, which is involved in memory and learning processes. ...
The findings could help develop new treatments for neurodegenerative diseases such as Alzheimer's and Parkinson's, and help understand how to keep the brain healthy as we age. ...
Neurological diseases, including Alzheimer's disease (AD), are often considered "incurable" because conventional small molecules cannot interfere with the function of disease-associated proteins. ...
Current psychiatrists benefit a lot from whole exome sequencing, as it solves the problem above. Take Alzheimer's disease as an example. Alzheimer's disease is a chronic degenerative disease resulting in dementia. ...
To understand the significance of the SpinTech MRI STAGE software platform, it helps to begin by asking a question: Given that MRI is an incredibly powerful diagnostic tool for neurological diseases like Alzheimer’s, dementia, Parkinson’s and multiple sclerosis (MS), why have radiologists and neurologists had to choose between conducting faster MRI exams and obtaining ...