Antigen Sequence Articles & Analysis
8 articles found
In biomedical research, antibodies are a powerful tool used in the detection and quantification of target antigens. However, a comprehensive understanding of the antibody requires knowledge of its amino acid sequence, which can be achieved through antibody sequencing.Antibody sequencing is a nucleic acid sequencing process that ...
In the environment of cancer, antigens may be specific to tumor cells and are known as tumor-specific antigens (TSAs) or tumor-associated antigens (TAAs). ...
Each T cell typically expresses a specific TCR, which has a unique structure and sequence that can recognize different antigens, including bacteria, viruses, tumor cells, and other pathogens. ...
Therapies based on mAbs have now become the gold standard for cancer treatment, and the number and types of clinically applicable mAb-based therapies are also increasing.1. Antibody SequencingAntibody sequencing can reveal antigen-antibody binding affinity, antibody epitopes, and post-translational modifications, and precise antibody characterization can ensure ...
Mapping Epitopes and Paratopes Through antibody sequencing, we can determine epitopes (binding sites of antigens) and paratopes (binding sites of antibodies), reveal information that helps to draw epitope maps, guide antibody design, and paratope variations, which can enhance the specificity of antibody drugs. ...
Additionally, SignalTACs containing the RRRRK sequence, based on Trastuzumab (Tz) modification (Ab6), exhibited the highest internalization capability. Structure-activity relationship studies indicated that the double leucine-based sequence DEDLL (Asp7-Ile11) is critical for its function. Moreover, truncation of 13 residues at P1 of the sequence ...
Tuberculosis - a deadly disease with a huge global burden Tuberculosis continues to be the most serious cause of death from a single infectious micro-organism. Drug resistant tuberculosis is a particularly insidious manifestation of this disease for which alternative approaches to conventional therapy are required to facilitate treatment. Despite heroic efforts to develop new drugs to treat ...
A combination of bioinformatics approach and computational tools are used to screen and select antigen sequences as potential T-cell epitopes of supertype human leukocyte antigens (HLAs) alleles. This includes identification of epitopes from the transmembrane proteins sequences across Plasmodium genera. These epitopes have high ...