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Biomarker Articles & Analysis
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Marrying this approach with the ability to deploy a biomarker-based strategy for selecting targeted patient cohorts can significantly derisk the clinical trial process ...
It is also employed as a standard in ELISA kits designed to quantify circulating levels of MGP or its modified forms (e.g., desphospho-uncarboxylated MGP, dp-ucMGP), which are emerging biomarkers for cardiovascular risk stratification. MGP as a Disease Biomarker and Therapeutic Target Altered MGP expression or modification status has been implicated in numerous ...
It allows them to: Diagnose and Monitor Disease: Quantifying specific sterols can serve as biomarkers for various metabolic disorders. Advance Pharmaceutical Research: Understanding how a drug interacts with sterol pathways is crucial for developing new therapies, from cholesterol-lowering statins to novel antifungal agents. ...
By revealing the intricate landscape of protein ubiquitination, researchers can identify novel drug targets and potential biomarkers for disease. This powerful analysis is not just expanding our fundamental understanding of the cell; it is actively paving the way for the next generation of diagnostics and therapeutics. ...
This technology is indispensable for discovering new diagnostic biomarkers and therapeutic targets, pushing the boundaries of our understanding of the dynamic regulatory networks that govern life. ...
Such investigations may lead to the discovery of novel biomarkers or therapeutic targets for kidney diseases. Ethical considerations regarding the use of human cells are also addressed with immortalized podocyte lines. ...
This profiling can reveal the context-dependent effects of inhibitors and identify biomarkers for patient stratification in clinical trials. By understanding the kinase landscape within specific tumors, researchers can tailor treatments to enhance efficacy and reduce toxicity. ...
Enzymes like glucose oxidase and horseradish peroxidase form the backbone of diagnostic biosensors, offering high sensitivity and specificity for detecting biomarkers in complex biological fluids. Additionally, application of enzymes in the treatment of diseases is rapidly expanding. ...
Similarly, studies are investigating the use of BCL2 family gene profiling as a potential biomarker to predict patient response to therapy. This gene profiling could help clinicians design personalized treatment strategies based on the specific apoptotic pathways that are dysregulated in a patient’s cancer cells. ...
The Technical Revolution in Glycan Analysis Modern glycomics leverages breakthrough technologies that have transformed the field: Nano-LC-MS/MS with electron-transfer dissociation capturing fragmentation patterns impossible with earlier techniques Isotope-coded glycan tagging enabling precise quantitative comparisons across disease states MALDI-imaging mass spectrometry visualizing glycan ...
Ischaemic heart diseases continue to be a major global health concern and a leading cause of death. To develop more effective treatments, it is essential for researchers to work with animal models that closely replicate human cardiac physiology. In a notable step forward, Pius et al. present a refined, minimally invasive ovine model of ischaemia–reperfusion–infarction which ...
By examining the levels of TCA Cycle intermediates and associated metabolites, scientists can gain insights into cellular metabolism and identify biomarkers for health and disease. Creative Proteomics offers specialized TCA Cycle Analysis services that provide researchers with detailed profiling of TCA intermediates and related metabolites. ...
Customized assays can help identify biomarkers and therapeutic targets. Drug Development: Evaluating the impact of new drugs on cytokine profiles is essential for assessing their efficacy and safety. ...
Not all patients respond to immunotherapy, and researchers are working to identify biomarkers that can predict who will benefit most from these treatments. ...
The development of reliable and reproducible resistance models remains a significant issue, as does the identification of biomarkers that predict response to therapy. Additionally, the dynamic nature of resistance means that continuous monitoring and adaptation of treatment strategies are essential. ...
These enhanced diagnostic tools not only facilitate timely interventions but also enable the identification of specific biomarkers that inform personalized treatment plans aimed at optimizing patient outcomes. ...
This multiplexing ability is critically important for researchers analyzing complex biological pathways, immune responses, and disease biomarkers. At the heart of the Luminex system lies a set of microspheres (beads), each uniquely coated with specific antibodies and labeled with distinct fluorescence signatures. ...
These nano-sized particles contain a diverse array of molecular cargo, including proteins, lipids, RNA, and metabolites, which serve as biomarkers for a variety of physiological conditions. Exosome lipidomics and metabolomics are key fields that focus on profiling the lipids and metabolites present in exosomes. ...
Understanding and analyzing these biomolecules has become increasingly important in areas such as disease research, biomarker discovery, and drug development. NAD and NADH are not merely passive participants in metabolism—they are regulatory molecules that influence key metabolic pathways, including glycolysis, oxidative phosphorylation, and biosynthetic reactions. ...
Disease Research: By mapping altered flux patterns in cancer cells, cardiovascular diseases, or diabetes, MFA helps identify potential metabolic vulnerabilities or biomarkers for diagnosis and therapy. Agricultural Sciences: MFA can uncover mechanisms by which plants adapt to environmental stresses, aiding in crop improvement. ...