Body Simulation Articles & Analysis
2 articles found
Even so, the standard paradigm for preclinical ADME data translation includes: (1) testing a compound in preclinical subjects and collect outputs, (2) building 1- or 2-compartment model of compound PK, or use physiologically-based pharmacokinetic models (PBPK), (3) fitting model parameters to the compound PK data, (4) scaling optimized parameters to human relevant values using established ...
The cements were evaluated regarding the pH-variation in simulated body fluid (SBF). Further, the biocompatibility of the cement with human mesenchymal stem cells (MSC) was studied in vitro and eventual inflammation properties studied in vivo, after subcutaneous material injections in rats. ...