Cancer Cell Articles & Analysis: Older
234 articles found
They are adept at identifying and destroying infected or cancerous cells. However, their natural capacity may not always be sufficient to combat complex diseases. ...
Bladder cancer, characterized by the uncontrolled proliferation of abnormal cells within the bladder lining, poses significant treatment challenges due to its potential to invade surrounding tissues and surrounding propensity for recurrence. ...
Breast cancer remains one of the most prevalent malignancies affecting women worldwide, necessitating innovative approaches for effective treatment and research. ...
Researchers can then probe these arrays with various samples to study interactions between glycans and proteins, antibodies, or even cells. This high-throughput technology allows researchers to simultaneously analyze thousands of carbohydrate-related interactions and gain insights into their biological significance. ...
This mimetic action allows researchers to enhance or restore the expression of target genes that are otherwise downregulated in diseases such as cancer, neurodegenerative disorders, and cardiovascular diseases. Mechanism of Action Upon introduction into cells, miRNA mimics enter the RNA-induced silencing complex (RISC), where they bind to complementary mRNA ...
For instance, researchers can introduce a reporter gene under the control of a promoter that responds to a drug target, allowing them to visually assess the compound’s effect on gene expression. In cancer research, reporter stable cell lines can help illuminate tumor behavior. By labeling cancer cells with a fluorescent or ...
It acts like a skilled architect, carefully laying down the blueprint for the mRNA that mirrors the DNA template. In eukaryotic cells, RNA polymerase II is specifically responsible for synthesizing mRNA. ...
There are several approaches to generate human cancers in zebrafish, such as the development of mutant and transgenic cell lines and transplantation of tumor cells, each with several advantages and disadvantages. ...
Precision-Cut Lung Slices (PCLS) have emerged as a innovative ex vivo model that allows researchers to explore deep into lung physiology, disease mechanisms, and pharmacological responses. By offering a unique combination of biological complexity and controlled experimental conditions, PCLS serve as a critical bridge between the limitations of traditional in vitro cell cultures and the ...
Gene delivery in cancer treatment involves the use of viral or non-viral vectors to deliver therapeutic genes into cancer cells. These approaches allow the targeted delivery of genes that can inhibit tumor growth or enhance the immune system's capability to recognize and destroy cancer cells. One promising ...
Discover how matched tumor-normal sequencing can help clinical researchers detect the somatic origin of variants with certainty. In the era of precision oncology, it has become increasingly common for patients diagnosed with cancer to undergo tumor sequencing. Identifying the mutations that make up a tumor’s genomic landscape can help guide selection of targeted therapies and inform ...
When a ribosome is affixed to the polypeptide (protein) it is making, the ribosome-nascent chain complex (RNC) is the compilation of molecules that make up the ribosome. One of several methods can be used to halt the synthesis of the nascent polypeptide. RNCs are made and purified in labs to study the dynamics, biochemistry, folding, and interactions that the ribosome and proteins undergoing ...
The emergence of chimeric antigen receptor T-cell (CAR-T) therapy has revolutionized the treatment of certain cancers, providing a promising targeted approach to eliminate cancer cells. ...
Understanding Clonality Analysis Clonality refers to the origin of a cell population from a single 'parent' or progenitor cell through asexual reproduction or division. This concept is vital in cancer studies as it helps track the development of tumor cells from a single mutated cell. Clonality analysis is thus ...
Tumor cells differ significantly from normal cells in their energy metabolism. ...
Cell Analysis for Brain Tumors Cell analysis, particularly at the single-cell level, provides deep insights into the cellular heterogeneity within brain tumors. ...
Ensure Specificity and TargetingThe main advantage of ADC lies in its high specificity for specific cancer cell surface antigens. Biological activity analysis can verify whether ADC can accurately identify and bind to target antigens. This not only helps ensure therapeutic effects but also reduces non-specific damage to healthy cells.2. Evaluate ...
They are generally proteins or polysaccharides found on the surface of pathogens, such as viruses, bacteria, or cancer cells. In the environment of cancer, antigens may be specific to tumor cells and are known as tumor-specific antigens (TSAs) or tumor-associated antigens (TAAs). Antibodies, also known as immunoglobulins, are ...
This synergistic approach allows for targeted delivery of the cytotoxic agent to cancer cells while sparing healthy tissues, thereby reducing side effects and enhancing therapeutic efficacy. ...
The T cell antigen receptor (TCR) is a characteristic marker of T cells, playing a crucial role in the immune system. Each T cell typically expresses a specific TCR, which has a unique structure and sequence that can recognize different antigens, including bacteria, viruses, tumor cells, and other pathogens. Once the TCR binds to the antigen, the T cell initiates an immune response, generating ...