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Cancer Cell Articles & Analysis
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Many oncology drugs have been abandoned by pharmaceutical companies due to poor performance in phase I, II, or III clinical trials. These drugs represent untapped potential treatments for indications outside of those initially investigated. With research and development costs for a single new drug estimated between $2–3 billion, abandoned drugs represent an opportunity to bring drugs to ...
Population growth, aging populations and increases in cancer incidence have necessitated new approaches to identifying effective treatments. ...
Human ovarian epithelial cells play a crucial role in ovarian function and have become a significant focus in cancer research, specifically ovarian cancer. ...
Post-transcriptional modifications of RNA molecules include methylation, acetylation deamination, isomerization, glycosylation, thiolation and pseudouracil modification among other types. Methylation represents the predominant post-transcriptional modification found within transfer RNA (tRNA) molecules. tRNA methylation has maintained its evolutionary conservation while also exhibiting dynamic ...
Unlike other viral vectors, lentiviruses can transduce both dividing and non-dividing cells, broadening the scope of potential applications. This property is particularly beneficial for targeting tissues that are not actively dividing, such as neurons and certain types of stem cells. ...
Adenoviruses are a group of viruses that have gained significant attention in recent years, particularly in the fields of gene therapy, vaccine development, and cancer treatment. With their ability to deliver genetic material into cells effectively, adenoviruses serve as valuable vectors in various biomedical applications. ...
Antibody-drug conjugates (ADCs) combine potent small-molecule drugs with monoclonal antibodies for targeted cancer therapy. A major challenge is loading enough drug onto each antibody without compromising solubility or circulation time. ...
It belongs to a larger BCL2 gene family, which includes both pro-apoptotic and anti-apoptotic proteins that maintain a delicate balance between cell survival and cell death. Dysregulation of this gene family is implicated in a variety of diseases, most notably cancer. ...
These specialized compounds often target cancer by interfering with cell division, signal transduction, or angiogenesis processes. Modern oncology APIs include targeted therapies like kinase inhibitors and monoclonal antibodies that precisely attack cancer cells while minimizing damage to healthy tissues. The manufacturing of ...
Cancer treatment has witnessed transformative advancements over the past few decades, notably with the emergence of CAR-T (Chimeric Antigen Receptor T-cell) therapy. This revolutionary therapy harnesses the body's immune system by genetically engineering T-cells to target and destroy cancer cells. Among the ...
The conventional treatment approaches fail to accurately target cancer cells, which results in numerous adverse effects while diminishing treatment success. ...
Researchers are increasingly focused on engineering antibodies that can selectively target specific cancer cells or diseased tissues while minimizing off-target effects. ...
Circulating Tumor Cells, or CTCs, are cancer cells that have shed from the primary tumor and enter the bloodstream, where they can travel and potentially lead to metastasis. ...
When PD-1 molecules on platelets interact with anti-PD-1 on tumor cells they release drugs that eliminate regulatory T cells while boosting CD8+ T cell functions which helps decrease tumor recurrence and metastasis after surgery. ...
The pioneering initiative represents a major advancement in targeting cancer treatments to destroy malignant cells effectively while reducing damage to healthy tissues. ...
These innovative therapeutic agents combine the targeting capabilities of antibodies with the cytotoxic effects of radioactive isotopes, providing a powerful strategy for precision cancer treatment. Understanding Radioactive Drug Conjugates Radioactive drug conjugates are engineered to deliver radiation directly to cancer cells while sparing ...
The monoclonal antibody is designed to bind specifically to cancer cells, ensuring that the toxic drug is delivered directly to the tumor, thereby minimizing damage to healthy cells. ...
For instance, HA-based scaffolds are being developed to promote bone regeneration, while HA nanoparticles are engineered to deliver drugs directly to cancer cells, minimizing side effects. l Nanotechnology and Surface Engineering The synthesis of nano-sized HA particles has opened new doors for precision medicine. ...
ByMatexcel
One of these impressive solutions is radiopaque markers – small devices used to diagnose and treat a variety of conditions, ranging from cardiovascular problems to cancer. Not only do they help doctors better understand what’s going on inside patients’ bodies, but they also provide an important bridge between traditional medicine and modern alternatives by ...
Watertown, MA – March 24, 2025 – Biopharma PEG, a leading supplier of high-quality polyethylene glycol (PEG) derivatives, highlights its innovative product DSPE-PEG-Mannose, an advanced biomedical polymer with significant potential in drug delivery, tumor-targeted therapy, tissue recognition, and adhesion.Structural Advantages of DSPE-PEG-MannoseDSPE-PEG-Mannose is composed of three key ...