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Cell Therapies Articles & Analysis
112 articles found
The BCL2 gene, short for B-cell lymphoma 2, is a critical regulator of apoptosis, or programmed cell death. ...
By administering recombinant chemokines, scientists can redirect immune cells to the tumor microenvironment, potentially enhancing the efficacy of checkpoint inhibitors or CAR-T cell therapies. ...
Cancer treatment has witnessed transformative advancements over the past few decades, notably with the emergence of CAR-T (Chimeric Antigen Receptor T-cell) therapy. This revolutionary therapy harnesses the body's immune system by genetically engineering T-cells to target and destroy cancer cells. Among the ...
Podocytes are specialized epithelial cells located in the kidneys, playing a crucial role in the filtration barrier of the glomerulus. These unique cells have garnered significant attention in scientific research due to their pivotal function in maintaining kidney health and their involvement in various kidney diseases. ...
Unlocking the Power of Organoids Organoids are three-dimensional structures that replicate the functions of actual organs within the body. They develop from progenitor cells, which researchers obtain either from embryonic tissues or pluripotent stem cells (PSCs). ...
Alfa Cytology employs state-of-the-art techniques including isolation, culture, engineering, expansion, and characterization of immune cells and stem cells to develop novel cell therapies. These innovative solutions are grounded in a comprehensive understanding of tumor biology and immune system dynamics, empowering researchers ...
Both concepts encapsulate the complexity of cellular processes and open new avenues for targeted therapies. What is Synthetic Lethality? Synthetic lethality occurs when the simultaneous disruption of two genes leads to cell death, whereas the disruption of either gene alone does not affect cell survival. ...
By harnessing the natural capabilities of the immune system, immuno-oncology services are revolutionizing the way we approach cancer treatment, offering novel therapies that are changing the prognosis for many patients. Understanding Immuno-Oncology Immuno-oncology focuses on the interaction between the immune system and cancer cells. ...
These findings could improve our understanding of neurological disorders such as autism and epilepsy. 3. Protein Mapping in Cell Cycle Phases A 2024 study mapped out thousands of proteins involved in cell division, providing a molecular blueprint for developing more targeted cancer therapies. Implications for Cancer Treatment Since ...
This initiative signifies a major leap forward in the development of more effective cancer therapies, aiming to boost both precision and versatility within treatment paradigms. As cancer treatment methodologies continue to evolve, there is an escalating demand for innovative and personalized approaches. Traditional therapies often lack the specificity needed to ...
Among the various forms of immunotherapy, CAR T-cell therapy (Chimeric Antigen Receptor T-cell therapy) has shown promise, particularly in treating acute lymphoblastic leukemia (ALL), especially in children and young adults. This therapy involves genetically modifying a patient’s T-cells to ...
These technologies allow scientists to cut, insert, or modify specific DNA sequences, enabling the customization of T cells to recognize and attack disease-specific antigens. Applications in Cancer Therapy One of the most promising applications of gene editing in primary T cells is in cancer therapy. ...
They are synthesized and secreted by a range of immune cells, including monocytes, macrophages, T cells, B cells, and natural killer (NK) cells, as well as certain non-immune cells like endothelial cells, epidermal cells, and fibroblasts. Cytokines are produced in response to ...
Human umbilical cord cells, particularly those found in Wharton’s jelly, have emerged as a focal point in regenerative medicine and cellular therapy. ...
In recent years, research has focused on the unique properties of corneal epithelial cells, particularly their regenerative capabilities. Under normal conditions, these cells can heal minor injuries efficiently. ...
GMP growth factors and cytokines designed for therapeutic manufacturing are an essential component of defined media. To date, the cell therapy industry has accepted GMP terms for this reagent class, despite the fact that there is no direct oversight by regulators. These proteins are intended for use in further manufacturing processes and do not come into direct ...
In cancer research, zebrafish models have advantages over traditional cell culture assays because a wider range of phenotypes can be tested. ...
Human brain has approximately 171 billion cells, of which slightly more than half (approximately 86 billion) are nerve cells. These 86 billion nerve cells are a diverse cell population with hundreds of specialized types and functions, but all originate from three neural cell lineages--neurons, oligodendrocytes and astrocytes. All three cell lineages originate from a pool of neural stem and ...
This article aims to engage in an incisive analysis of cell and gene therapies, decoding their transformative implications on human health and medical research. Cell therapy constitutes a form of treatment where live cells are induced into a patient's body to effectuate reconstruction or repair of damaged ...
The emergence of chimeric antigen receptor T-cell (CAR-T) therapy has revolutionized the treatment of certain cancers, providing a promising targeted approach to eliminate cancer cells. ...