Colitis Articles & Analysis
17 articles found
Beyond sepsis, TREM1 has been implicated in the pathogenesis of inflammatory bowel diseases (IBD), such as Crohn’s disease and ulcerative colitis. Studies have demonstrated elevated levels of TREM1 in the inflamed intestinal tissues of IBD patients, signifying its involvement in perpetuating the chronic inflammation characteristic of these conditions. ...
In a mouse model, oral administration of IL-22 mRNA-loaded LNP significantly increased IL-22 expression in the colonic mucosa and accelerated the healing of colitis. These results suggest that oral delivery of mRNA-loaded LNP is a viable strategy for treating gastrointestinal diseases by reestablishing the intestinal microenvironment. 2) Inhalation is also a preferred route of ...
Cytokines in Inflammatory Bowel Disease (IBD) IBD, chronic gastrointestinal inflammation encompassing Crohn's disease (CD) and ulcerative colitis (UC), results from imbalanced interactions between mononuclear phagocytes, Foxp3+ Treg cells, B cells, and cytokines from intestinal epithelial cells (IECs) and immune cells. ...
It and chronic non-specific ulcerative colitis are collectively known as inflammatory bowel disease (IBD). The disease is active with shortening and thickening of the villi and deep ulceration and necrosis of epithelial cells, causing pathological changes such as reduction in mucosal area and abnormal function. ...
We maintain our commitment to their diagnosis, with kits for the in vitro diagnosis of the following rare diseases*: Rare Disease : Diagnostic tests Cystic fibrosis or fibrocystic disease of the pancreas : Determination of 50 cystic fibrosis mutations in patients and relatives by genetic analysis Multiple sclerosis : Determination of anti-ganglioside and anti-myelin-associated glycoprotein ...
Higher levels of circulating immune complexes are also seen in ulcerative colitis, Crohn's disease, and AIDS. Protease helps keep airways open Proteases break down mucus that blocks the airways. ...
Furthermore, TNF-a represents the most validated clinical target for ulcerative colitis (UC) and inflammatory bowel diseases (IBD) with multiple emerging neutralizing/inflammation-reducing therapeutics targeting this cytokine for inactivation. ...
Research Achievements of Human Microbiome In recent years, with the continuous research on the human microbiome, gut microbes have been found to be closely related to a variety of human diseases, including not only digestive tract diseases such as colitis and colon cancer (these digestive tract diseases, flora, and digestive tract are in direct contact), but also metabolic ...
However, some patients with partial loss of STAT1 function (LOF) have chronic colitis, as well as severe infections. On the other hand, individuals with enhanced STAT1 function (GOF) mutations most commonly suffer from mucocutaneous disease, in part due to reduced levels of TH17 cells, thereby attributing important regulatory functions to STAT1. ...
A major clinical and research focus is IBD, which is a broad term encompassing ulcerative colitis (UC) and Crohn’s disease (CD), as it effects a significant portion of the population, yet few treatments have been discovered. ...
The aim of this study was to investigate the capabilities and mechanisms of Lactobacillus acidophilus (L. acidophilus) KBL402 and KBL409 treatment in the alleviation of colitis using the in vivo dextran sodium sulfate (DSS)-induced colitis mice model. Various colitis symptoms of mice, including disease activity index score [4.55 ± 0.99 (P ...
Sinha et al.31, reported thatRuminococcaceae were depleted and stool secondary bile acid levels were reduced in patients with ulcerative colitis, and that the supplementation of LCA ameliorated inflammation in the animal colitis model, implicating the potential therapeutic role ofRuminococcaceae in gut microenvironment. ...
In accordance with previous study gut microbiota was altered in the progression of colitis, with a reduced relative abundance of S24–7_unclassified and increased Bacteroides and Mucispirillum.37 On the other hand, we observed an increased abundance of S24–7_unclassified with administration of KBL365 or KBL382, and decreased abundance of Bacteroides and Mucispirillum ...
The abundance of genus Bacteroides is highly correlated with the occurrence of colitis (Lucke et al., 2006). Previous studies have also reported that genus Mucispirillum showed the an association with chemical-induced or Citrobacter rodentium-induced colitis in mice (Loy et al., 2017) and Sutterella species were associated with low secretory IgA levels due to ...
It can be used in conjunction with other auxiliary therapies to treats medical conditions that include: Skin and soft tissues diseases: Thermal burns, chemical burns, radiation burns Frostbite Scalds Skin infections (erysipelas, pyoderma, actinomycosis, aspergillosis, Gram negative bacteria infections, nosocomial infections) Dry skin Cutaneous ulceration (caused by vein insufficiency , ...
After World War II, the number of new people getting inflammatory bowel disease (Crohn’s disease and a related condition called ulcerative colitis) skyrocketed across the West in countries such as the U.S., Canada and the UK. ...
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Conflict of interest statement Competing Interests: The authors have the following interests: John Conly has received honoraria from the Canadian Agency for Drugs and Technologies in Health for work as an expert reviewer and clinical expert, respectively, for projects on the role of rapid PCR testing for MRSA in hospitalized patients and the use of vancomycin or metronidazole for treatment of ...