Drug Evaluation Articles & Analysis
33 articles found
The MDCK permeability assay is a critical technique employed in pharmacology and drug development to evaluate the permeability of drug candidates across epithelial cell layers. ...
Additionally, this analysis supports drug development by evaluating the effects of therapeutic agents on tissue structures. ...
This article explores the importance of drug screening in drug-resistant cells and its implications for advancing therapeutic strategies. ...
The evolution of 3D printing technology has opened up new avenues in the pharmaceutical industry, especially in the fabrication of novel drug delivery systems. One such advancement is the 3D printing of Oral Thin Films (OTFs), which are ultra-thin films used to deliver drugs via oral mucosa. ...
The evaluation of cardiovascular toxicity is a significant challenge in drug development. Preclinical evaluation of cardiovascular safety involves a multifaceted approach, encompassing a plethora of in vitro and in vivo endpoints. ...
Pharmaceutical Development: These cell lines are essential in the drug discovery pipeline, allowing for high-throughput screening and functional assays to evaluate drug efficacy and safety. ...
However, these models sometimes failed to predict the proarrhythmic potential of certain compounds, leading to unexpected issues in later drug development stages. CiPA aims to offer a more holistic approach by evaluating multiple ion channels and utilizing advanced in silico modeling, providing a better prediction of cardiac risk. ...
Antibody drugs are a type of drugs that treat diseases through artificially synthesized antibodies, which bind specifically to target molecules for therapeutic purposes. ...
Recombinant protein drugs are protein-based therapeutic drugs which are produced by using DNA recombination technology or other biotechnological methods. ...
Therefore, the detection of sialic acid proteins holds significant value in disease diagnosis, biomedical research and drug development.Biological Importance of Sialic Acid ProteinsSialic acid proteins play an indispensable role in many physiological and pathological processes. ...
The scientific realm behind the development and evaluation of therapeutic drugs, pesticides, industrial and environmental chemicals profoundly relies on a field of research called Pharmacokinetic/Toxicokinetic (PK/TK) studies. ...
Applications: Research: Mapping the architecture and alterations in the cytoskeleton in various diseases. Drug Discovery: Observing how pharmaceuticals affect cytoskeletal integrity. ...
This not only helps ensure therapeutic effects but also reduces non-specific damage to healthy cells.2. Evaluate Drug Release MechanismsAfter reaching the cancer cells, ADC needs to release the drug components into the cancer cells through an effective release mechanism. ...
Compared to protein drugs, peptide drugs also have advantages such as good stability, high purity, low production cost, and low immunogenicity. ...
There are many different molecules in ADCs, and the difference between these molecules lies in the drug-to-antibody ratio (DAR) value and/or the site where the antibody binds to the drug. ...
As a leading biotechnology company, MtoZ Biolabs is committed to providing comprehensive, one-stop CRO testing services to scientific research institutions and pharmaceutical companies worldwide. Whether in the early stages of drug discovery, candidate drug evaluation, or preclinical development, MtoZ Biolabs can provide professional technical ...
If a stroke occurs, brain cells will be damaged or even die within a short period of time, resulting in damage to the brain and the body will not be able to work properly. Screening and evaluation of safe and effective anti-stroke drugs can help in the treatment and prevention of the disease. Approaches to the Evaluation of Anti-stroke ...
Ribo-seq technology finds its applications across a diverse spectrum of fields within life sciences, including: (1) Gene Regulation Studies: Ribo-seq empowers researchers to delve deep into the intricate web of gene regulation by pinpointing the direct influence of transcription factors and miRNAs on gene expression at the translation level. (2) Drug Development: CD ...
Application of flow cytometry in drug development and research FC has a wide range of applications and participates in all aspects of the entire drug development process, including drug development and target confirmation, non-clinical safety and toxicity evaluation, and clinical research. 1. ...
In this article, we will delve into the methods involved in preparing drug microcapsules, methods for evaluating their performance, and the advantages they bring to the field of pharmaceuticals. ...