Drug Free Articles & Analysis
14 articles found
Adhesive-backed nasal strips are worn externally over the nose bridge to widen the nostrils for better breathing. These are available over-the-counter aids designed to improve airflow, nasal congestion and reduce ...
Role of Liposomes in Drug Delivery The structure of liposomes, consisting of an aqueous core enclosed by a lipid bilayer, allows for the encapsulation of both hydrophilic and lipophilic drugs. ...
Antibody-drug conjugates (ADCs) are a new class of drugs that combine the advantages of both antibodies and small molecule toxins. ...
There are many different molecules in ADCs, and the difference between these molecules lies in the drug-to-antibody ratio (DAR) value and/or the site where the antibody binds to the drug. In addition, ADCs prepared by the current production process usually contain non-ADC forms, including naked antibodies and free small molecule ...
Traditionally, copper-catalyzed azide-alkyne cycloaddition (CuAAC) has been the cornerstone of click chemistry, but concerns about cytotoxicity and metal contamination have sparked increasing interest in copper-free alternatives. This article explores the diverse applications of copper-free click chemistry in biomedical research, highlighting its potential for ...
The main considerations include optical chirality, polymorphism, impurities (product-related, process-related, free drugs and related substances, residual solvents, heavy metals), biological activity (target specific binding, affinity, effector function) and potency. ...
When the involved peptide is a depsipeptide (X=O in Figure 1), the formation of DKP is accelerated, as hydroxy derivatives act as better leaving groups than their amino counterparts.FDA-approved Peptide DrugsConsidering the common occurrence of degradation in peptides with Nα groups, whether the N-terminus should be blocked to prevent DKP formation becomes a crucial consideration in peptide ...
Biological Analysis of ADC In order to characterize the PK characteristics of different ADC components, several analytical methods are required: (1) ELISA determines the kinetic curves of the conjugate and total antibody. (2) TFC-MS/MS can quantify the free drugs or metabolites. (3) High-resolution mass spectrometry for in vivo drug antibody ...
Pulmonary administration of drug-loaded liposomes can prolong the topical and systemic therapeutic effects of drugs. ...
After completing all the necessary studies demonstrating that the gel-based, drug-free product works as a self-care treatment for ED, Futura says it is confident that the soon to be submitted de novo medical device application will be successful and pave the way for a Q1 2023 launch. Minute Insight: Viagra May Face Stiff US Competition From Futura’s ...
In medicine, taking a holistic approach means treating the whole person - body, mind, spirit, and emotions - to achieve one’s optimal health and wellness. For example, if a patient comes in with a sharp, jabbing pain in his hand - a symptom of peripheral neuropathy - a holistic treatment plan may not only include pain relief medicine but also address underlying causes of pain. A holistic ...
Please browse PolyMem.com, which includes a References section containing a large volume of literature about PolyMem, to learn more about PolyMem dressings: Unique components work with the body and each other to facilitate rapid wound healing Balances wound moisture and conforms well; benefits every wound type The drug-free dressings that actually ...
Innovations and Iterations In the consumer tech world, iterations happen very fast, though most inventions are not ‘one and done’ masterpieces: the Dyson cyclone vacuum cleaner made 5,127 prototypes. In the medical device world, development takes longer because of the appropriate and necessary regulations and need for safety. Using an agile approach, but with safety and reliability ...
So, what, according to research, are the 5 most effective drug-free treatments for depression? According to the latest health research, there are at least 5 different ways to effectively treat depression without any medication. ...