Drug Induced Articles & Analysis
13 articles found
At the heart of this initiative are CiPA Translational Assays, designed to improve the prediction of drug-induced cardiac arrhythmias. Understanding the CiPA Initiative CiPA was launched with the goal of addressing limitations in existing proarrhythmia models. ...
Light Stability Analysis Light stability analysis is another important technique used in stability analysis to study the effect of light exposure on the stability of a drug. Light can cause the degradation of certain drugs, leading to a decrease in their potency and safety. By studying the impact of light on the stability of a drug, ...
This unusual repolarization can cause recurrent syncope, seizures, and even sudden cardiac death due to its proclivity to cause life-threatening ventricular tachyarrhythmias known as Torsades de Pointes. Furthermore, susceptibility to drug-induced long QT syndrome (diLQTS) can also be linked to hERG-related abnormalities. ...
This platform enables antibody-mediated targeted delivery to achieve a high degree of tumor specificity, while using infrared light to activate the biophysical mechanism of the drug to accurately induce rapid death of cancer cells without harming surrounding normal tissue. ...
It is also increasingly applied in drug development. FC not only can detect intracellular and extracellular components, but also detect soluble analytes in serum or plasma samples, such as cytokines, drug complexes, or anti-drug antibodies (ADA). ...
The patient had a SVR >1200 dynes for more than 88% of the case indicating physiological or drug-induced vasoconstriction. Argos provided data that consistently showed the subtle changes in hemodynamics helping to inform decisions for a more targeted ...
He is currently testing a preventive cancer vaccine, which induces an immune response to peptides produced from mutated messenger RNA (mRNA), in a $6 million, 5-year study in dogs. ...
ByCalviri
Overcoming issues of heterogeneity in disease classification and enabling new approaches to successful drug development. SLE is an autoimmune disease with a wide range of clinical manifestations. ...
An alleviating effect of R. faecis on fibrosis was shown with H&E and Sirius red staining (Fig. 8c), and the histological severity of NAFLD induced by an MCD diet was significantly regressed in mice fed R. faecis (Fig. 8d, e). ...
Though this has reduced oncology patients’ infectious exposure, it has created the dilemma for laboratory and vital sign monitoring for patients at risk for drug-induced toxicities. Tools that facilitate social distancing while maintaining connectivity to the healthcare system and providing objective data for ongoing management are urgently needed [16,17]. ...
Durham, NC (April 28, 2020) - A review article published in PNAS highlights Symberix's efforts to understand the role of the human microbiota in drug efficacy and toxicity. Symberix co-founder Matt Redinbo is featured in the article alongside other leaders from the emerging field of “pharmacomicrobiomics” -- the study of mechanisms behind the microbial impact on ...
Durham, NC (February 3, 2020) - An article in Nature highlights Symberix's efforts to understand the complex relationship between drugs and the microbiome. The paper discusses recent contributions to the emerging field of “pharmacomicrobiomics” -- the study of how microbes impact drug disposition, efficacy, and toxicity. Symberix is developing ...
Attempts have been made to investigate the reproductive toxicity of norfloxacin drug in Japanese quail. Male quail were administered with norfloxacin @ 20 mg/kg body weight for 14 days. ...