Drug Use Articles & Analysis: This-Year
8 articles found
Many oncology drugs have been abandoned by pharmaceutical companies due to poor performance in phase I, II, or III clinical trials. These drugs represent untapped potential treatments for indications outside of those initially investigated. With research and development costs for a single new drug estimated between $2–3 billion, abandoned drugs represent an opportunity to bring drugs to ...
Chemical Synthesis Chemical synthesis remains one of the most widely used techniques for lipid production due to its versatility and control over molecular structure. ...
One such advancement is the establishment of the Monkey DLL3 stable cell line using HEK293T cells. This article provides an overview of the significance of this cell line, its applications, and the methodology behind its development. ...
Various species, including rodents, primates, and even larger mammals, are employed depending on the disease context and research requirements. Types of Animal Models Used in Drug Screening Diverse animal models are utilized in drug screening, with each offering unique advantages. ...
Preclinical drug discovery represents a critical phase in the development of new therapeutics. ...
One notable case is the development of antiviral agents, where phosphorus compounds serve as critical intermediates. The synthesis of drugs targeting viral infections often involves the use of phosphoramidites, which are derived from phosphorus oxychloride. ...
They are FDA-approved and often used in various applications, from sutures to drug delivery systems. ...
The evaluation of cardiovascular toxicity is a significant challenge in drug development. Preclinical evaluation of cardiovascular safety involves a multifaceted approach, encompassing a plethora of in vitro and in vivo endpoints. These assessments continuously evolve, aiming to mitigate the incidence of cardiovascular toxicity that may emerge during clinical trials. To shed light on the ...