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Drug Use Articles & Analysis
121 articles found
Many oncology drugs have been abandoned by pharmaceutical companies due to poor performance in phase I, II, or III clinical trials. These drugs represent untapped potential treatments for indications outside of those initially investigated. With research and development costs for a single new drug estimated between $2–3 billion, abandoned drugs represent an opportunity to bring drugs to ...
Chemical Synthesis Chemical synthesis remains one of the most widely used techniques for lipid production due to its versatility and control over molecular structure. ...
One such advancement is the establishment of the Monkey DLL3 stable cell line using HEK293T cells. This article provides an overview of the significance of this cell line, its applications, and the methodology behind its development. ...
Various species, including rodents, primates, and even larger mammals, are employed depending on the disease context and research requirements. Types of Animal Models Used in Drug Screening Diverse animal models are utilized in drug screening, with each offering unique advantages. ...
Preclinical drug discovery represents a critical phase in the development of new therapeutics. ...
They are FDA-approved and often used in various applications, from sutures to drug delivery systems. ...
One notable case is the development of antiviral agents, where phosphorus compounds serve as critical intermediates. The synthesis of drugs targeting viral infections often involves the use of phosphoramidites, which are derived from phosphorus oxychloride. ...
The evaluation of cardiovascular toxicity is a significant challenge in drug development. Preclinical evaluation of cardiovascular safety involves a multifaceted approach, encompassing a plethora of in vitro and in vivo endpoints. These assessments continuously evolve, aiming to mitigate the incidence of cardiovascular toxicity that may emerge during clinical trials. To shed light on the ...
At present, recombinant protein drugs are widely used in various fields such as tumors, autoimmune diseases, metabolic diseases, geriatric diseases, and degenerative diseases.FcyR (Fc gamma receptors) are receptors expressed on the surface of immune cells, primarily responsible for recognizing and binding to the Fc (Fragment crystallizable region) part of ...
Condensation Polymerization: In this method, copolymers are formed by the reaction between two different monomers, typically involving the elimination of a small molecule (such as water). This process is commonly used in producing polyesters and polyamides and is advantageous for creating specialty copolymers. ...
This method involves conducting the reaction in solution, with protective groups used to prevent unwanted side reactions. Applications of Synthetic Peptides The versatility of synthetic peptides allows them to serve numerous roles across various fields: Pharmaceutical Development One of the most significant applications of synthetic peptides is in drug ...
Peptide drugs are bioactive protein fragments composed of short chains of amino acids. ...
In light of the recent act that has just come into force, the use of electronic cigarettes is now going to be heavily regulated. Although Malaysia has not banned the use of e-cigarettes like some neighbouring countries, the stricter regulations present a challenging position within the region regarding this issue. ...
AUC uses centrifugal force and centrifugation time to analyze the sedimentation behavior of molecules in the solution, which can provide important information about the structure, interactions, and purity of the drug. The specific applications of AUC in antibody drugs include:Purity and aggregation analysis of antibody ...
Recombinant protein drugs are protein-based therapeutic drugs which are produced by using DNA recombination technology or other biotechnological methods. ...
Recombinant protein drugs refer to protein products derived from animals or plants and developed through biotechnology research. ...
This testing is crucial because these host cell proteins (HCPs) may impact the safety, efficacy, and quality of drug products.In the fields of biotechnology and biopharmaceuticals, commonly used drugs such as monoclonal antibodies and other recombinant proteins are often produced in cell culture systems, such as E. coli, CHO (Chinese Hamster ...
Recombinant protein drugs are therapeutic protein drugs produced using DNA recombination technology or other biotechnologies. ...
Glycosylated impurities refer to a kind of glycosylated product formed during the synthesis, storage, and use of drugs, mainly resulting from non-enzymatic reactions between sugars and drug molecules. ...
Medical ResearchGene knockout is often used in medical research to study human diseases. For example, by knocking out genes associated with diseases, scientists can better understand the roles of these genes in diseases.2. Drug DevelopmentGene knockout is also used in drug development. By knocking out drug target ...