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Elemental Analysis Articles & Analysis

13 articles found

Application of R3/R5 Microwave Digestion Systems in the Elemental Analysis of Active Pharmaceutical Ingredients (APIs)

Application of R3/R5 Microwave Digestion Systems in the Elemental Analysis of Active Pharmaceutical Ingredients (APIs)

This application demonstrates the use of the R3/R5 microwave digestion systems to prepare samples of carbamazepine, an active pharmaceutical ingredient (API), for trace metal analysis. The method ensures complete digestion with minimal loss of volatile elements, making it ideal for regulated pharmaceutical ...

ByTianezk Instrument Manufacturing (Chengdu) Co., Ltd.


CMC Regulatory Considerations for ADCs

CMC Regulatory Considerations for ADCs

Characterization of mAb intermediates includes primary structure (amino acid sequence, N-terminal/C-terminal sequence analysis, peptide map), secondary or tertiary structure, protein fragments/aggregates, and charge variants, glycosylation modification, post-translational modification, target binding properties and biological activity, etc. ...

ByBOC Sciences


CD Genomics Takes Genomic Research to New Heights with Ribo-seq Technology

CD Genomics Takes Genomic Research to New Heights with Ribo-seq Technology

This technology empowers researchers to explore translation efficiency, initiation sites, regulatory elements, and post-translational modifications on specific genes, offering profound insights into protein synthesis and regulation. ...

ByCD Genomics


Finite Element Study of a Lumbar Intervertebral Disc Nucleus Replacement Device

Finite Element Study of a Lumbar Intervertebral Disc Nucleus Replacement Device

Probabilistic analysis was performed on the normal model to provide quantitative validation metrics. Sensitivity analysis was performed on the silicone Shore A durometer of the device. ...

BySpinal Stabilization Technologies, LLC


Eight Commonly Used Techniques for Drug Analysis

Eight Commonly Used Techniques for Drug Analysis

Drug analysis refers to the detection and analysis of ingredients and contents in drugs. ...

ByCD Formulation


Development of a Bioartificial Vascular Pancreas

Development of a Bioartificial Vascular Pancreas

To determine the ultimate utility of the BVP concept and to optimize parameters of its design, we performed in silico modeling (computersimulations) using finite element analysis. These results were validated by in vitro bioreactor studies designed to mimic oxygen levels in implanted BVP constructs. ...

ByHumacyte, Inc.


Three generations of ADC: Nearly a decade of development-PI

Three generations of ADC: Nearly a decade of development-PI

Antibody-drug conjugate (ADC), a compound that connects a cytotoxic small-molecule drug to a monoclonal antibody via a rationally established linker, which selectively delivers an efficient cytotoxic agent into the tumor, has made significant progress in the previous decade. The first ADC drug approved by the US FDA was gemtuzumab ozogamicin (Mylotarg) in 2009. Currently, the FDA has authorized ...

ByCreative Biolabs


A hybrid modeling approach for assessing mechanistic models of small molecule partitioning in vivo using a machine learning integrated modeling platform

A hybrid modeling approach for assessing mechanistic models of small molecule partitioning in vivo using a machine learning integrated modeling platform

There are different model modalities, such as compartment-based models that characterize organs as well-perfused and well-mixed, finite element analysis (FEA), and three-dimensional recapitulations of tissue structures18, 19. ...

ByVeriSIM Life


Performance Tes-ng of an Injectable Silicone Rubber Based Nucleus Replacement Device

Performance Tes-ng of an Injectable Silicone Rubber Based Nucleus Replacement Device

Samples of this device were subjected to finite element analysis (FEA), digital pressure mapping and biomechanical flexibility tes-ng to determine the impact of the device on disc structure and biomechanical ...

BySpinal Stabilization Technologies, LLC


Synthesis of biphasic calcium phosphate powders by a simple hydrolysis process

Synthesis of biphasic calcium phosphate powders by a simple hydrolysis process

Phase identification, microstructural observations and elemental analysis of the as–synthesised BCP particles are conducted by using X–ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), environmental scanning electron microscopy (ESEM) and X–ray fluorescence (XRF).Keywords: tricalcium phosphate, hydroxyapatite, hydrolysis, biphasic calcium ...

ByInderscience Publishers


Ultrastructural characterisation of the hydroxyapatite–coated pedicle screw and human bone interface

Ultrastructural characterisation of the hydroxyapatite–coated pedicle screw and human bone interface

Focused ion beam sample preparation also enabled the investigation of the bone–lacunae interface. An intimate contact and elemental analysis between bone and HA coatings suggests bioactive fixation. ...

ByInderscience Publishers


Element profiles in hair and nails of children reflect the uptake from food and the environment

Element profiles in hair and nails of children reflect the uptake from food and the environment

To this purpose, the element concentrations in hair and nails were related to element concentrations measured in food items, water, and soil. ...

ByJohn Wiley & Sons, Ltd.


Platform technologies to support brain-computer interfaces

Platform technologies to support brain-computer interfaces

The demonstrations are conducted using mathematical and finite element analysis, physical experiments, and animal experiments. The fundamental concepts of the biofuel cells are presented and three versions of the cells that have been studied are discussed, including bacteria-based cells and two white cell-based experiments. ...

ByComputational Diagnostics, Inc. (CDI)

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