Endocrine Activity Articles & Analysis
4 articles found
Definitions of Active Pharmaceutical Ingredients, Emerging Contaminants & Endocrine Disrupting Compounds All drugs are made up of two core components — the active pharmaceutical ingredient or API which is the central ingredient, and an excipient. ...
ByCoftec
The US Environmental Protection Agency has responsibility for assessing endocrine activity of more than 10 000 chemicals, a task that cannot reasonably be achieved solely through use of available mammalian and nonmammalian in vivo screening assays. Hence, it has been proposed that chemicals be prioritized for in vivo testing using data from in vitro ...
This paper reports on short‐term fish reproduction assays in zebrafish and fathead minnow conducted to examine the potential for methyl tertiary butyl ether (MTBE) to cause effects on the endocrine system. Both studies were performed under Good Laboratory Practice and in accordance with OECD and USEPA test guidelines. Results of the first study demonstrated that exposure to a high test ...
Chemical analysis of 17β‐estradiol, estrone and 17α‐ethinylestradiol levels showed that they accounted for the majority of the observed in vitro estrogenic activity in the final effluents but only 18 to 70% of estrogenic activity in the influents. Removal efficiency for androgenic activity was 97.5 to 100%. Endocrine ...