Endocrine Study Articles & Analysis
11 articles found
Endocrine disrupting compounds (EDCs) can impact the reproductive system by interfering with the hypothalamic‐pituitary‐gonadal (HPG) axis. While in vitro testing methods have been developed to screen chemicals for endocrine disruption, extrapolation of in vitro response to in vivo action shows inconsistent accuracy. ...
Dolan analyzes and interprets endocrine study results, placing results in context so that clients can make astute regulatory and business decisions. ...
The chemical UV filter benzophenone‐3 (BP‐3) is suspected to be an endocrine disruptor based on results from in vitro and in vivo testing. However, studies including endpoints of endocrine adversity are lacking. The present study investigated the potential endocrine disrupting effects of BP‐3 in zebrafish ...
This paper reports on short‐term fish reproduction assays in zebrafish and fathead minnow conducted to examine the potential for methyl tertiary butyl ether (MTBE) to cause effects on the endocrine system. Both studies were performed under Good Laboratory Practice and in accordance with OECD and USEPA test guidelines. ...
Interactions between insulin signaling and steroidogenesis suggest potential endocrine‐disrupting effects of metformin found in the aquatic environment. ...
As knowledge of contaminants capable of adversely modulating endocrine functions increases, attention is focused on the effects of synthetic progestins as environmental endocrine disrupters. In the present study, effects of exposure to a synthetic progestin (norethindrone, 168 ± 7.5 ng/L) and endogenous progestogen (progesterone, 34 ± 4.1 ng/L) ...
TBECH has been detected in the environment and in previous in silico and in vitro studies we have shown that TBECH can activate both the human androgen receptor (hAR) and the zebrafish AR (zAR) suggesting that it is a potential endocrine disruptor. The present study was aimed at determining the interaction of TBECH with the chicken AR (cAR). ...
Pentachlorophenol (PCP) is frequently detected in the aquatic environment and has been implicated as an endocrine disruptor in fish. In the present study, 4‐month‐old zebrafish (Danio rerio) were exposed to 1 of 4 concentrations of PCP (0.1, 1, 9, and 27 µg/L) for 70 d. ...
Great concern has been raised over the potential impact of environmental contaminants on fish populations that inhabit in the Three Gorge Reservoir (TGR). In the present study, we investigated the endocrine disrupting effects of di‐(2‐ethylhexyl)‐phthalate (DEHP), on the Chinese rare minnow (Gobiocypris rarus), an endemic fish distributing upstream waters in ...
Tributyltin (TBT) and triphenyltin (TPT) are emblematic endocrine disruptors, which have been mostly studied in gonochoric prosobranchs. ...
The U.S. Environmental Protection Agency (EPA) issued its final list of chemicals in the first group of substances that will be screened under the Endocrine Disruptor Screening Program (EDSP).1 Development of this list caps a long, thoughtful, and arduous administrative process that spans over a decade. This “Washington Watch” column briefly reviews the development of the program, with emphasis ...