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Gastric Acid Articles & Analysis

4 articles found

Pharmacokinetic Characteristics of Monoclonal Antibody Drugs

Pharmacokinetic Characteristics of Monoclonal Antibody Drugs

The reasons include: 1) Protein is easy to denature in acidic gastric juice; 2) Protein is easily degraded by a large number of hydrolytic enzymes in the gastrointestinal tract; 3) Protein is large and polar, so it is not easily absorbed by gastrointestinal epithelial cells through diffusion. ...

ByCreative Proteomics


Rani developing technology for oral delivery of injectable biologics

Rani developing technology for oral delivery of injectable biologics

Imran explains that RaniPill is protected by a polymer coating that prevents disintegration by highly acidic gastric acid in the stomach. After passing through the stomach and arriving in the small intestine, the coating and capsule begin to break down in response to the more alkaline intestinal fluid. ...

ByRani Therapeutics


Design and R&D of Covalent Drugs

Design and R&D of Covalent Drugs

Another approach is to structurally modify natural products to obtain compounds that are more effective, such as salicylic acid to aspirin, morphine to methadone. According to statistics, about 60% of the drugs in clinical practice are obtained based on the above strategy. ...

ByBOC Sciences


Vaginal lactobacilli inhibit growth and hyphae formation of Candida albicans

Vaginal lactobacilli inhibit growth and hyphae formation of Candida albicans

We selected the L. crispatusSNUV220 and L. fermentumSNUV175 strains for further analysis based on their anti-Candidagrowth activity and probiotic characteristics, such as resistance to gastric acidity, bile acid resistance and anti-microbial activity. We hypothesised that vaginal Lactobacillusstrains secrete pH-independent antifungal compounds ...

ByKoBioLabs

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