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Genomics Research Articles & Analysis

46 articles found

Optimizing HindII Digestion Protocols for Challenging DNA Templates in Advanced Molecular Biology Applications   

Optimizing HindII Digestion Protocols for Challenging DNA Templates in Advanced Molecular Biology Applications  

For example, HindII/HpaII comparative digestion patterns can reveal methylation states at hundreds of genomic loci simultaneously. This approach provides a broader genomic view than targeted bisulfite sequencing while requiring significantly less sequencing depth. ...

ByCreative Enzymes


Optimizing HindII Digestion Protocols for Challenging DNA Templates in Advanced Molecular Biology Applications   

Optimizing HindII Digestion Protocols for Challenging DNA Templates in Advanced Molecular Biology Applications  

For example, HindII/HpaII comparative digestion patterns can reveal methylation states at hundreds of genomic loci simultaneously. This approach provides a broader genomic view than targeted bisulfite sequencing while requiring significantly less sequencing depth. ...

ByCreative Enzymes


Fosmid Library Construction: A Comprehensive Overview

Fosmid Library Construction: A Comprehensive Overview

Fosmid libraries represent a pivotal advancement in the field of genomics and molecular biology, offering a robust method for genomic cloning and analysis. ...

ByCreative Biogene


Genome Editing in Model Plants: A Paradigm Shift in Plant Science

Genome Editing in Model Plants: A Paradigm Shift in Plant Science

Genome editing, a transformative technology in genetic research, has revolutionized the way scientists study and modify plant genomes. ...

ByCreative Biogene


Knockin Cell Line Generation: A Frontier in Genetic Engineering

Knockin Cell Line Generation: A Frontier in Genetic Engineering

Knockin cell line generation represents a pivotal advancement in genetic engineering, providing vital tools for biological research and therapeutic development. This process involves the integration of specific DNA sequences into precise loci within the genome, allowing scientists to explore gene function, model diseases, and develop new treatments. Understanding ...

ByCreative Biogene


An Insight into Reporter Stable Cell Lines: Advancements and Applications

An Insight into Reporter Stable Cell Lines: Advancements and Applications

By integrating a reporter gene into the genome of a cell, researchers can create a stable cell line that emits a measurable signal in response to specific stimuli or conditions. ...

ByCreative Biogene


Utilizing Zebrafish Genome Editing Services: Shaping the Future of Genomic Research

Utilizing Zebrafish Genome Editing Services: Shaping the Future of Genomic Research

Within the rapidly advancing realm of biotechnology, zebrafish genome editing services are carving a niche, heralding a new epoch in genomics and cellular research. ...

ByCreative Biogene


Sequencing Depth, Coverage and Read Types for NGS   

Sequencing Depth, Coverage and Read Types for NGS  

Coverage is the proportion of the final result to the whole genome. For example, if a human genome is sequenced and the coverage is 98.5%, then it means that there is still 1.5% of the genome that cannot be obtained by our assembly and analysis; for depth, it is the average number of times a single base on the genome being ...

ByCD Genomics


Antibody Sequencing: Insights for Drug Design

Antibody Sequencing: Insights for Drug Design

However, its throughput is relatively low and cannot meet the current demand for information depth in complex genomic research problems. Against this backdrop, Next-Generation Sequencing (NGS) was born. ...

ByMtoZ Biolabs


Variant Analysis Workflow in Bioinformatics   

Variant Analysis Workflow in Bioinformatics  

Introduction to Variant Analysis Rare DNA changes within a population of cells are the first manifestations of mutations, which are the fuel for evolution. The research of genomic variation between species and individual organisms has been revolutionized by next-generation sequencing (NGS) technologies. ...

ByCD Genomics


Homologous Recombination-mediated Genome Editing Service

Homologous Recombination-mediated Genome Editing Service

As a global leader in recombination-mediated genome editing service, Creative Biogene is dedicated to provide a number of services to achieve scientific results faster than ever before. We have a team of passionate and talented scientists who have years of experience and would work closely with you to provide help in reducing your workload while raising the visibility of your ...

ByCreative Biogene


CD Genomics Takes Genomic Research to New Heights with Ribo-seq Technology

CD Genomics Takes Genomic Research to New Heights with Ribo-seq Technology

Expert Team: CD Genomics boasts an experienced research team capable of tailoring experimental designs and data analysis to specific research objectives. ...

ByCD Genomics


Utilizing Zebrafish Genome Editing Services: Shaping the Future of Genomic Research

Utilizing Zebrafish Genome Editing Services: Shaping the Future of Genomic Research

Within the rapidly advancing realm of biotechnology, zebrafish genome editing services are carving a niche, heralding a new epoch in genomics and cellular research. ...

ByCreative Biogene


Pan-Genome Analysis: Overview, Workflow, Application and Recent Advances

Pan-Genome Analysis: Overview, Workflow, Application and Recent Advances

What is pan-genome? A pan-genome is the sum of all genomic information within a species. With the development of genomic technology, researchers have found that a single reference genome can no longer meet the needs of genomic data analysis, and more and more species, including ...

ByCD Genomics


Whole Genome Sequencing for Rare Diseases

Whole Genome Sequencing for Rare Diseases

However, with recent advancements in technology, specifically in the realm of genomics, whole genome sequencing (WGS) has emerged as a powerful tool that has revolutionized the diagnosis and management of rare diseases. ...

ByProtheragen


Single Guide RNA Libraries: Their Applications and Future Potential in Biotechnology

Single Guide RNA Libraries: Their Applications and Future Potential in Biotechnology

These studies have immense implications in medical research, where understanding the gene-disease dynamics is paramount. sgRNA based genetic screens provide a robust platform for functional genomics, promoting research in fields such as oncology, immunology, and molecular biology. ...

ByCreative Biogene


Differential Gene Expression (DGE) Analysis in RNA Sequencing

Differential Gene Expression (DGE) Analysis in RNA Sequencing

DEGs, or Differentially Expressed Genes, are genes whose expression levels show significant differences between two or more conditions or experimental groups. In genetics and genomics research, gene expression refers to the process by which information encoded in a gene's DNA sequence is converted into functional proteins or RNA molecules. ...

ByCD Genomics


Single-Cell RNA Sequencing in Drug Discovery and Development

Single-Cell RNA Sequencing in Drug Discovery and Development

Furthermore, scRNA-seq is increasingly employed in functional genomics screens, where researchers perturb cells and assess their response using high-throughput methods. ...

ByCD Genomics


Analytical Approaches and Applications of Whole Exome Sequencing (WES) in Oncology

Analytical Approaches and Applications of Whole Exome Sequencing (WES) in Oncology

Introduction Genomics has revolutionized cancer research, transforming the way we diagnose, treat, and monitor cancer. ...

ByCD Genomics


SuperCut Series: Redefining Enzyme Tools for Precision Research and Applications

SuperCut Series: Redefining Enzyme Tools for Precision Research and Applications

Enzymes, as crucial catalysts in biological systems, play a significant role in scientific research and industrial applications. To enhance efficiency in research and application, enzyme scientists have continuously sought innovative enzyme tools. ...

ByCreative Enzymes

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