Gleason Score Articles & Analysis
7 articles found
The literature shows that pathologists, being only humans under considerable pressure, may miss cancer in up to 1-3% of prostate biopsies.2,3,4 Considering the over one million men who are diagnosed worldwide per year, this may reflect a large number of patients.5 Moreover, the subjectivity of Gleason grading and tumor quantification can result in difficulty assigning effective ...
Urinary HOXC6 and DLX-1 mRNAs were quantified by PCR in May 2018, and RNA results combined with clinical risk factors to determine the likelihood that biopsy would identify ISUP grade group (GG) ≥ 2 (Gleason Score ≥ 7) PCa. We assessed SelectMDx performance for detection of GG ≥ 2 PCa, compared to the PCPT Risk Calculator Version 2.0 (PCPTRC, ...
For these subjects, the SelectMDx risk score combined with TRUS was calculated, together with their PI-RADS scores (version 2). The inclusion cut-off for the model was set to 10% chance for high-grade PCa (≥ Gleason Score 3+4). Positive mpMRI was defined as PI-RADS score 4 or 5. ...
Of the subjects with PCa, 54 (67%) were diagnosed with Gleason score (GS) ≤6 PCa and 27 (33%) with GS ≥7 disease. For detection of PCa at repeat biopsy, ConfirmMDx sensitivity was 74.1% and specificity was 60.0%, equivalent to prior studies (P = .235 and .697, respectively). ...
The blinded validation project involves two phases, and the first has been completed: Phase I: Blinded third party validation of the test for men with aggressive PCa, Gleason score of 7(4+3), 8, 9, and 10 against men without any form of PCa, not cancer. ...
Here, it is investigated whether, in methylation-positive men, DNA-methylation intensities could help to identify those men harboring high-grade (Gleason score ≥7) PCa, resulting in an improved positive predictive value. ...
CASE REPORT A 66-year-old presented to us who, three years earlier, had undergone high-intensity-focused ultrasound (HIFU) treatment for organ-confined (Gleason score 3+4) prostate cancer. Approximately 3 months after the procedure, he presented to his local urologist with progressive-obstructive voiding symptoms that were managed endoscopically via visual ...