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Gleason Score Articles & Analysis

7 articles found

The Power of Digital Pathology: Why Labs Everywhere Should Make the Switch

The Power of Digital Pathology: Why Labs Everywhere Should Make the Switch

The literature shows that pathologists, being only humans under considerable pressure, may miss cancer in up to 1-3% of prostate biopsies.2,3,4 Considering the over one million men who are diagnosed worldwide per year, this may reflect a large number of patients.5 Moreover, the subjectivity of Gleason grading and tumor quantification can result in difficulty assigning effective ...

ByPaige AI, Inc.


Validation of a two-gene mRNA urine test for detection of high-grade prostate cancer in German men.

Validation of a two-gene mRNA urine test for detection of high-grade prostate cancer in German men.

Urinary HOXC6 and DLX-1 mRNAs were quantified by PCR in May 2018, and RNA results combined with clinical risk factors to determine the likelihood that biopsy would identify ISUP grade group (GG) ≥ 2 (Gleason Score ≥ 7) PCa. We assessed SelectMDx performance for detection of GG ≥ 2 PCa, compared to the PCPT Risk Calculator Version 2.0 (PCPTRC, ...

ByMDxHealth


Assessment of a urinary TRUS/biomarker-based risk score as inclusion criteria for multiparametric MRI to detect clinically significant prostate cancer

Assessment of a urinary TRUS/biomarker-based risk score as inclusion criteria for multiparametric MRI to detect clinically significant prostate cancer

For these subjects, the SelectMDx risk score combined with TRUS was calculated, together with their PI-RADS scores (version 2). The inclusion cut-off for the model was set to 10% chance for high-grade PCa (≥ Gleason Score 3+4). Positive mpMRI was defined as PI-RADS score 4 or 5. ...

ByMDxHealth


Evaluation of an Epigenetic Assay for Predicting Repeat Prostate Biopsy Outcome in African American Men

Evaluation of an Epigenetic Assay for Predicting Repeat Prostate Biopsy Outcome in African American Men

Of the subjects with PCa, 54 (67%) were diagnosed with Gleason score (GS) ≤6 PCa and 27 (33%) with GS ≥7 disease. For detection of PCa at repeat biopsy, ConfirmMDx sensitivity was 74.1% and specificity was 60.0%, equivalent to prior studies (P = .235 and .697, respectively). ...

ByMDxHealth


Blinded Validation Projectfor Prostate Cancer Test Johns Hopkins University Medical Center, Brady Urology Institute

Blinded Validation Projectfor Prostate Cancer Test Johns Hopkins University Medical Center, Brady Urology Institute

The blinded validation project involves two phases, and the first has been completed: Phase I: Blinded third party validation of the test for men with aggressive PCa, Gleason score of 7(4+3), 8, 9, and 10 against men without any form of PCa, not cancer. ...

ByOTraces Inc.


Risk score predicts high-grade prostate cancer in DNA-methylation positive, histopathologically negative biopsies

Risk score predicts high-grade prostate cancer in DNA-methylation positive, histopathologically negative biopsies

Here, it is investigated whether, in methylation-positive men, DNA-methylation intensities could help to identify those men harboring high-grade (Gleason score ≥7) PCa, resulting in an improved positive predictive value. ...

ByMDxHealth


Treatment of Post, High-Intensity-Focused Ultrasound Urethral Stricture with Novel Long-term Stent

Treatment of Post, High-Intensity-Focused Ultrasound Urethral Stricture with Novel Long-term Stent

CASE REPORT A 66-year-old presented to us who, three years earlier, had undergone high-intensity-focused ultrasound (HIFU) treatment for organ-confined (Gleason score 3+4) prostate cancer. Approximately 3 months after the procedure, he presented to his local urologist with progressive-obstructive voiding symptoms that were managed endoscopically via visual ...

ByAllium Ltd

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