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Human Disease Articles & Analysis
74 articles found
It recognizes a specific target protein and facilitates the final transfer of ubiquitin from the E2 enzyme to that protein. The human genome contains hundreds of different E3 ligases, each responsible for selecting a specific set of proteins, ensuring incredible specificity. ...
Moreover, in model organism studies, CRISPR/Cas9 lentiviral systems are employed to create stable cell lines or animal models that replicate human diseases, facilitating drug discovery and therapeutic development. Conclusion The CRISPR/Cas9 lentivirus production service represents a crucial advancement in gene editing technology, offering researchers a potent ...
Unlike conventional pharmaceuticals, many nutraceuticals focus on maintaining optimal health rather than treating specific diseases. Modern research increasingly validates the role of these compounds in supporting immune function, cognitive health, and metabolic processes. ...
The Importance of the Rat Model in Immunological Studies Rats are widely used in biomedical research due to their physiological and genetic similarity to humans. Their size, ease of handling, and well-characterized immune system make them ideal candidates for studying disease mechanisms and therapeutic interventions. Understanding the cytokine and chemokine ...
It is the process that bridges the gap between basic research and clinical testing, allowing for the evaluation of potential drug candidates in biological systems before they are tested in humans. Central to this phase is the use of appropriate disease models, which are essential for understanding the mechanisms of disease and assessing the ...
Animal models offer researchers valuable insights that cannot be obtained through in vitro studies alone, bridging the gap between laboratory research and human application. Understanding the Importance of Animal Models Animal models serve as biological proxies for human disease, allowing scientists to study complex biological interactions and ...
Disruptions in these controls can lead to uncontrolled cell division, a hallmark of cancer and other diseases. Cell cycle progression is orchestrated by key proteins, including cyclins, cyclin-dependent kinases (CDKs), and tumor suppressors. ...
Disease Research: By mapping altered flux patterns in cancer cells, cardiovascular diseases, or diabetes, MFA helps identify potential metabolic vulnerabilities or biomarkers for diagnosis and therapy. ...
Non-alcoholic fatty liver disease (NAFLD) has emerged as a significant public health concern, associated with obesity, insulin resistance, and a spectrum of metabolic disorders. ...
These protein drugs exhibit certain biological activity and can prevent, diagnose, and treat diseases in humans, animals, and plants. Compared with small molecular drugs, recombinant protein drugs offer advantages such as high activity, high specificity, and low toxicity, and are therefore favored by researchers. At present, recombinant protein drugs are widely ...
Researchers can add tags, fluorescent markers, or reporter genes to visualize cellular processes in real-time. Disease Modeling: Knockin cell lines mimic human disease conditions by introducing disease-related genetic mutations, thus offering a robust platform to study pathophysiology and screen potential therapeutic ...
For such critical samples, especially those from diseased human biopsies, high-quality media are required. This reduces the risk of contamination and saves time, labor and money by eliminating required preparation steps and replenishment. ...
These proteins possess certain biological activities and can prevent, treat, and diagnose diseases in humans, animals, and plants. Compared to small molecule drugs, protein drugs have advantages such as high activity, high specificity, and low toxicity, making them highly favored by researchers. Currently, protein drugs are widely used in various fields, ...
It can also be used to study the mechanisms of some diseases, such as cancer, genetic diseases, and infectious diseases.1. Medical ResearchGene knockout is often used in medical research to study human diseases. For example, by knocking out genes associated with diseases, scientists can better ...
Autophagy has also been implicated in pathological conditions including neurodegenerative diseases, cancer, and inflammatory diseases. Modulation of autophagy has become a potential therapeutic target in human diseases. ...
Recently developed CRISPR/Cas9-based screening methods have great potential for revealing the mechanisms and treatment strategies of human diseases, but there are still some biological studies that are not suitable for CRISPR knockout screening. ...
Genomic engineering in cell lines is a versatile tool for studying gene function, designing diseases models, biopharmaceutical research, drug discovery and many other applications. ...
Disturbances in metabolic pathways can lead to many common human diseases such as cancer, diabetes, obesity, hypoglycemia, hypolipidemia, phenylketonuria, neurodegeneration, etc. ...
MMP-2 and MMP-9 play a role in chronic kidney disease. MMP-9 has also been proposed as a therapeutic target for Alzheimer's disease and type 2 diabetes. ...
By utilizing a panel of stable cell lines, researchers can systematically investigate the impact of gene activation on various cellular processes, identifying potential therapeutic targets or biomarkers for disease. Furthermore, CRISPRa stable cell lines provide a platform for studying the functional consequences of genetic variants or mutations associated with ...