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Immune Defense Articles & Analysis

9 articles found

Understanding Protein Ubiquitination and Cellular Health  Ā 

Understanding Protein Ubiquitination and Cellular Health Ā 

However, other chains, like the K63-linked one, send non-destructive signals involved in crucial processes like DNA repair and immune signaling. Why Is This Process So Important? The versatility of the ubiquitin code makes it a master regulator of cellular life. ...

ByCreative Proteomics


Vaccinia Virus Capping Enzyme: A Vital Enzyme in the Viral Replication Cycle

Vaccinia Virus Capping Enzyme: A Vital Enzyme in the Viral Replication Cycle

At the heart of the virus's replication process lies the Vaccinia virus capping enzyme, a multifunctional protein that plays a crucial role in ensuring the successful expression of viral genes and the evasion of host immune defenses. Structure and Catalytic Domains The Vaccinia virus capping enzyme is a large, multidomain protein that consists of three distinct ...

ByCreative Enzymes


The Science Behind Dietary Supplements: Exploring Efficacy and Safety of Popular Ingredients

The Science Behind Dietary Supplements: Exploring Efficacy and Safety of Popular Ingredients

They serve as coenzymes in enzymatic reactions, regulate gene expression, and play important roles in immune function and antioxidant defense. A study by Hemilä and Chalker (2013) published in Cochrane Database of Systematic Reviews highlighted the potential benefits of vitamin C supplementation in reducing the duration of common cold episodes. ...

ByAlfa Chemistry


Mechanisms to Combat Drug Resistance: Overview of Antimicrobial Peptides

Mechanisms to Combat Drug Resistance: Overview of Antimicrobial Peptides

These peptides play a crucial role in the innate immune system's defense against microbial infections, exhibiting antimicrobial properties that can inhibit the growth or kill bacteria, fungi, viruses, and even some parasites. ...

ByBOC Sciences


CD19: One of The Most Important Targets for Car-T Cell Therapy

CD19: One of The Most Important Targets for Car-T Cell Therapy

It serves as a crucial marker for B cells, playing a pivotal role in the human immune system. While predominantly found on the surface of B cells, CD19 is rarely expressed on other immune cells. ...

ByBeta Lifescience


Ozette’s computationally-driven analysis aids advancement of cancer drug development - Case study

Ozette’s computationally-driven analysis aids advancement of cancer drug development - Case study

Pairing high parameter flow cytometry with Ozette’s next generation analysis helped decipher the complex immune landscape of tumors and revealed tumor-specific cell populations that modulate immune responses. ...

ByOzette Technologies


Introduction to Protein N-glycosylation

Introduction to Protein N-glycosylation

In mammals, N-glycosylation plays a part in regulating embryonic development, cancer occurrence and development, and immune defense. In plants, N-glycosylation is of great significance to many physiological processes such as cell wall formation, reproductive development, and resistance to pathogen invasion. Study of N- glycosylation in immune ...

ByCreative Proteomics


VIC Portfolio Companies and Pipeline Technologies with Pandemic Impact

VIC Portfolio Companies and Pipeline Technologies with Pandemic Impact

People with diabetes and associated poor glycemic control have a significantly weakened immune defense and are more adversely affected by viral infections. Hospitalized diabetic patients face longer hospitalization and recovery times. ...

ByNob Hill Therapeutics


Electronic cigarettes disrupt lung lipid homeostasis and innate immunity independent of nicotine

Electronic cigarettes disrupt lung lipid homeostasis and innate immunity independent of nicotine

In addition to ENDS-induced lipid deposition, chronic ENDS vapor exposure downregulated innate immunity against viral pathogens in resident macrophages. Moreover, independent of nicotine, ENDS-exposed mice infected with influenza demonstrated enhanced lung inflammation and tissue damage. Together, our findings reveal that chronic e-cigarette vapor aberrantly alters the physiology ...

ByJohnson Controls, Inc.

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